What are the specific factors that cause bone cancer?

Bone cancer is a disease of the bones of the human body. The real cause of bone cancer is still unclear. Experts speculate that it may be related to factors such as excessive bone growth, chronic inflammatory stimulation, metabolic problems and radiation. Next, let's explore the causes of bone cancer from the following article.

The pain mechanism of bone cancer caused by bone metastasis comes from the chemical and mechanical stimulation of tumor cells on the nociceptors on the bone or periosteum, as well as the pain caused by the infiltration of sensory nerves by bone cancer tumors. It is generally believed that bone destruction caused by bone cancer tumors, pathological fractures, involvement of the periosteum, nerve infiltration, and activation of nociceptors by neurotransmitters released by tumors are all causes of acute bone cancer.

When bone cancer destroys bone, it produces prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2), which can sensitize peripheral nerve endings; this persistent pain can cause sensitization of nociceptors (overreaction to harmful or non-harmful stimuli), and clinically, bone cancer patients show abnormal pain and hyperalgesia. Therefore, this is also a factor that leads to the etiology of bone cancer.

The above is a detailed description of the causes of bone cancer. I hope it can help everyone understand the knowledge of bone cancer and cure bone cancer in time. If you have other questions about bone cancer, you can contact our online experts to answer your questions.