What are the causes of colorectal cancer?

Colorectal cancer is a general term for rectal cancer and colon cancer, and is a common malignant tumor of the gastrointestinal tract. Some symptoms gradually become obvious. It is difficult to treat in the late stage. Here are the causes of colorectal cancer. The onset of colorectal cancer is related to bad living habits such as overnutrition. my country is a low-incidence area for colorectal cancer, but in recent years, with the change of lifestyle, its incidence rate has shown a clear upward trend. Moreover, the age of colorectal cancer in my country is 10 to 15 years earlier than that in foreign countries, which is a major feature. According to statistics, the high-incidence age of colorectal cancer in Europe and the United States is 60 to 70 years old, while most colorectal cancer patients in my country are 40 to 50 years old, with a median age of about 45 years old, 12 to 18 years earlier than in foreign countries.

1. Genetic factors There are reports of "family-based colorectal cancer" both at home and abroad. The number of blood relatives of colorectal cancer patients who died of the disease is significantly higher than that of the general population. Recently, some scholars have studied the relationship between tumor suppressor genes and colorectal cancer and found that the susceptibility and pathogenesis of colorectal cancer are related to genetic factors.

2. Colon adenoma According to the autopsy data from various places, the incidence of colon adenoma is quite consistent with that of colon cancer. According to statistics, the incidence of colon cancer in patients with one adenoma is 5 times higher than that in patients without adenoma, and the incidence of colorectal cancer in patients with multiple adenomas is 1 times higher than that in patients with a single adenoma.

3. Chronic colorectal inflammation: The risk of colorectal cancer in patients with chronic ulcerative colitis is 4 to 20 times higher than that in normal people. The risk of malignant transformation in patients with hemorrhagic ulcerative colitis is even greater. For patients with a disease course of more than 10 years, 50% will develop cancer.

4. Dietary factors Studies have shown that among various environmental factors, dietary factors are the most important. A large number of studies have shown that the incidence of colorectal cancer is positively correlated with the amount of fat consumed in food, and negatively correlated with the intake of vegetables and cellulose. A high-fat diet can increase the concentration of neutral cholesterol and bile acid in the large intestine, and affect the composition of intestinal bacteria that act on these products. Bile acid and neutral cholesterol have a similar three-dimensional structure to polycyclic aromatic hydrocarbons, and their degradation products also have carcinogenic or auxiliary carcinogenic effects. Cellulose can absorb water, adsorb harmful substances, increase the amount of feces, shorten their residence time in the intestine, and promote their excretion. Studies in recent years have shown that folic acid intake can reduce the risk of colon cancer, and vegetables are the main source of folic acid.

5. Other factors: schistosomiasis, pelvic radiation, environmental factors (such as molybdenum deficiency in the soil), smoking, etc.

6. According to traditional Chinese medicine, the causes of colorectal cancer are related to the six exogenous evils (wind, cold, heat, dampness, dryness, and fire), improper diet, internal injuries caused by the seven emotions, internal invasion of external evils, and deficiency of vital energy. The onset of colorectal cancer is the result of the interaction between internal and external factors. The external factors are the accumulation of evil toxins such as the six exogenous evils and harmful diet; the internal factors are the imbalance of viscera and meridians, and the deficiency of yin and yang, qi and blood. The evil toxins take advantage of the opportunity to enter the body and form damp heat, qi stagnation, blood stasis, fire poison, etc., while the deficiency of vital energy causes the evil toxins to gather for a long time and form a mass, resulting in tumors. Among them, improper diet is the main exogenous factor: long-term overeating of fatty and sweet foods or eating unclean foods by mistake, which hurts the spleen and stomach, causes dysfunction of transportation and transformation, and internal accumulation of damp heat, which stays in the intestines. If it does not go away for a long time, qi and blood will stagnate and cause colorectal cancer. The main internal cause is deficiency of vital energy: either insufficient constitution, old age and physical weakness, or long-term diarrhea and dysentery, deficiency of the spleen and stomach, and invasion of evil toxins, which cause phlegm and dampness, stagnation of qi and blood stasis in the body, which attack the intestines and cause colorectal cancer.

The above is an introduction to "What are the causes of colorectal cancer?" People who are related to the pathogenic factors of colorectal cancer are advised to take preventive measures against colorectal cancer. If you have other questions about colorectal cancer, please consult our experts online or call for consultation.

Colorectal cancer http://www..com.cn/zhongliu/dca/