The dangers of high immunoglobulin lge

When we go to the hospital for a physical examination, we often see some numbers that we don’t understand. However, the normal values ​​are generally marked on the test report, so we can roughly understand them as long as we compare them. Take immunoglobulin for example, it is classified into five major categories, one of which is called IgE. If its value is very high, it indirectly reflects that there is something wrong with our body. It is generally related to chronic diseases and immune system diseases, so what are the specific dangers?

Immunoglobulin refers to animal protein with antibody activity. It is mainly found in plasma, but also in other body fluids, tissues and some secretions. Most of the immunoglobulins in human plasma are present in gamma globulin (γ-globulin). Immunoglobulins can be divided into five categories: IgG, IgA, IgM, IgD, and IgE.

people. Immunoglobulin IgE (an antibody in the human body) is present in the blood. It is the Ig with the lowest content in normal human serum and can cause type I hypersensitivity reaction. The properties of IgE are mainly synthesized by B cells in the lymphoid tissue of the lamina propria of the respiratory and digestive tract mucosa, and are the mediating factor of allergic reactions. In 1966, Swedish and Japanese scholars, the Ishizaka couple, first isolated IgE from the serum of patients with ragweed allergy and proved that IgE is the mediator of allergic reactions. IgE is a cytotropic antibody and its content in normal human serum is extremely low, ranging from 10 to 10,000 U/ml. The serum IgE levels of allergic and parasitic patients are significantly higher than normal

High globulin levels are related to chronic liver disease and the body's immune system. Most of the immunoglobulins in human plasma are present in gamma globulin (γ-globulin). It can be divided into five categories, namely immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin D (IgD) and immunoglobulin E (IgE). Among them, IgG is the most important immunoglobulin, accounting for about 70% of human plasma immunoglobulin G, with a molecular weight of about 150,000 and a sugar content of 2-3%. IgG molecules are composed of 4 peptide chains. Among them, the peptide chain with a molecular weight of 25,000 is called a light chain, and the peptide chain with a molecular weight of 50,000 is called a heavy chain. The light chain and heavy chain are connected by disulfide bonds (—S—S—). Immunoglobulin is produced after the body is stimulated by antigens (such as pathogens). Its main function is to react immune to antigens and generate antigen-antibody complexes, thereby blocking the harm of pathogens to the body and making the pathogens lose their pathogenic effects. On the other hand, immunoglobulins sometimes play a pathogenic role. In patients with chronic hepatitis B, the ratio of white blood cells to globulin is inverted for a long time, and alert people to signs of liver cirrhosis.