Bilirubin-removing drugs

Bilirubin is a hormone in the body that is closely related to the gallbladder and liver. An increase in bilirubin levels in the body often means that there is something wrong with these two parts of the body, but in pregnant women it may be a physiological factor. If you want to reduce the bilirubin in your body, you should start from the liver. For example, some drugs containing oxalate inhibitors and stem cell growth-promoting ingredients can slowly reduce the bilirubin in the body.

Glycyrrhizic acid preparations, such as monoammonium glycyrrhizinate and diammonium glycyrrhizinate, have hormone-like and immunomodulatory effects, and have strong anti-inflammatory, liver cell membrane protection, immunomodulatory and liver function improvement effects. Studies have found that monoammonium glycyrrhizinate can weaken the ability of peripheral blood monocytes in patients with chronic hepatitis to produce interleukins and tumor necrosis factor, and may induce PBMC cell membranes to produce soluble IL-6 receptors, thereby reducing the abnormally elevated levels of IL-6 and TNF-α in patient serum and alleviating liver inflammation and immune damage. Monoammonium glycyrrhizinate can induce gamma-interferon, enhance the activity of natural killer cells, and has anti-inflammatory and detoxification effects.

Hepatocyte growth factor can significantly stimulate hepatocyte DNA synthesis and promote hepatocyte regeneration, and has a significant repair effect on hepatocyte necrosis and inflammatory damage. Silymarin and Sophora flavescens injection can also promote liver cell regeneration and recovery.

Some drugs improve liver function by promoting liver cell metabolism. For example, fructose 1,6-diphosphate can promote energy metabolism and sugar utilization in liver cells, increase intracellular ATP and stabilize lysosomal membranes. Potassium magnesium aspartate can promote the tricarboxylic acid cycle and ornithine cycle. Inosine can enhance the activity of multiple enzymes such as coenzyme A and pyruvate oxidase, and promote energy metabolism and protein synthesis in liver cells.

Adenosylmethionine and liver health can enhance the fluidity of liver cell membrane and the activity of transmembrane transport system, increase the activity of Na+/K+-ATPase, and enhance the fluidity of bile, thereby facilitating the uptake and secretion of bilirubin by liver cells. In addition, adenosylmethionine can also synthesize endogenous detoxification compounds through transsulfurization, which is beneficial to the detoxification of liver cells.

Reduced glutathione, tiopronin, vitamin C, anetholethione, FDP, etc. can promote the synthesis of superoxide dismutase, inhibit or reduce the production of free radicals, protect the structure of liver mitochondria, and fight against liver damage caused by various reasons.

Bifendate, diphenhydramine and glucuronolide can enhance the liver's detoxification function and have a protective effect against poisoning by various liver toxins.

Some drugs improve liver function mainly by improving microcirculation. Such as phentolamine, scopolamine, prostaglandin E1, heparin and low molecular weight heparin, nifedipine, sodium alginate and viper antithrombotic enzyme. Scopolamine also has hormone-like euphoric and sedative effects, which can improve clinical symptoms and regulate nervous and humoral immune functions in the short term. PGE1 can inhibit the destruction of liver cells by phospholipase; inhibit the release of TNF, thereby protecting liver cells; relieve the inhibition of DNA synthesis by nuclear histones and promote liver cell regeneration; may have a certain anti-liver fibrosis effect; can correct immune dysfunction and reduce liver necrosis and inflammatory cell infiltration. Heparin can also improve bile viscosity, which is beneficial for the dissolution of bile clots and the excretion of bilirubin.

Squalene extracted from shark liver has a function similar to that of red blood cells in taking up oxygen. It produces activated squalene oxide, improves the body's oxidation-reduction reaction, and improves liver cell regeneration and bile secretion function.