Can omeprazole treat gastritis?

In current clinical practice, omeprazole is mainly used to treat peptic ulcer bleeding and acute gastric mucosal inflammation, as well as viral gastric mucosal inflammation. It also has a good auxiliary therapeutic effect on severe damage after cerebral hemorrhage, gastrointestinal function, and recovery after surgery. It can also prevent gastric acid or reflux gastritis, but you should also be careful about complications and adverse reactions during use. Omeprazole is mainly used to treat gastritis and gastrointestinal diseases.

Function and use

1. Bleeding from peptic ulcer and anastomotic ulcer.

2. Acute gastric mucosal damage during stress and acute gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs;

3. It is also commonly used to prevent serious diseases (such as cerebral hemorrhage, severe trauma, etc.) and to prevent rebleeding after gastric surgery;

4. Prevent gastric acid reflux combined with aspiration pneumonia in patients after general anesthesia or major surgery and in weak and comatose patients.

5. Acid suppression for patients with reflux gastritis caused by excessive gastric acid, and patients with severe heartburn caused by excessive gastric acid.

6. For patients with peptic ulcer and gastric and duodenal erosion, Wuhan Boshi Gastroenterology Hospital often uses omeprazole in treatment.

[Precautions] 1. Do not use for more than 7 days. If symptoms do not improve or disappear, please consult a doctor or pharmacist. 2. Do not take it again within two months. If symptoms recur, seek medical attention immediately. 3. Do not use this product in the following cases: difficulty or pain in swallowing; vomiting blood; bloody or black stools. These may be signs of a serious condition, consult your doctor. 4. Patients with impaired liver function or abnormal blood count should use this product under the guidance of a physician. 5. If heartburn persists or worsens, please stop using this product and go to the hospital for treatment. 6. Children should use this product under the guidance of a physician. 7. Use with caution during pregnancy or lactation. 8. If you overdose or experience serious adverse reactions, please seek medical attention immediately. 9. People who are allergic to this product should not use it. People with allergic constitution should use it with caution. 10. It is forbidden to use this product when its properties change. 11. Please keep this product out of reach of children. 12. Children must use this product under adult supervision. 13. If you are using other medicines, please consult your physician or pharmacist before using this product.

[Use in Children] There is no experience in using this medicine in children and it is prohibited for use in infants and young children.

[Use in elderly patients] Not yet clear.

[Use in pregnant and lactating women] Although animal experiments have shown that this product has no fetal toxicity or teratogenicity, it is generally not used in pregnant women and should be used with caution in lactating women.

[Drug Interactions] 1. Avoid simultaneous use with oral imidazole antifungal drugs such as ketoconazole, itraconazole, miconazole and fluconazole. 2. The combined use of omeprazole and clarithromycin can increase the incidence of adverse reactions in the central nervous system (mainly headache) and gastrointestinal tract. 3. Avoid using it simultaneously with diazepam (Valium), phenytoin, warfarin, nifedipine, digoxin, cisapride, quinidine, cyclosporine, caffeine and theophylline. 4. Drug interactions may occur if used with other drugs. Please consult your physician or pharmacist for details.

【Overdose】 Not yet clear.

【Pharmacology and Toxicology】Proton pump inhibitor. This product is a fat-soluble weak alkaline drug that is easily concentrated in an acidic environment. Therefore, after oral administration, it can be specifically distributed in the secretory tubules of the gastric mucosal parietal cells and converted into the active form of sulfenamide in this high-acid environment. It then irreversibly combines with the sulfhydryl group of the H+, K+-ATPase (also known as the proton pump) in the secretory membrane of the parietal cells through a disulfide bond to form a complex of sulfenamide and the proton pump, thereby inhibiting the activity of the enzyme and blocking the final step of gastric acid secretion. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons.

[Pharmacokinetics] After oral administration, this product is absorbed through the small intestine and takes effect within 1 hour. The blood concentration reaches the peak value in 0.5 to 3.5 hours. The effect lasts for more than 24 hours. It can be distributed to tissues such as the liver, kidney, stomach, duodenum, and thyroid gland, and can easily pass through the placenta. The bioavailability of a single dose is usually about 35%, and that of multiple doses increases to about 60%. The plasma protein binding rate is 95% to 96%, and the plasma half-life is 0.5 to 1 hour, and 3 hours in patients with chronic liver disease. This product is metabolized in the body by the liver microsomal cytochrome P450 oxidase system, with about 80% of the metabolites excreted via urine and the rest secreted via bile and then excreted in the feces.