What causes high serum alkaline phosphatase levels?

Serum alkaline phosphatase needs to be checked through blood test results. What causes high serum alkaline phosphatase values? There are many reasons why the human body's serum alkaline phosphatase values ​​are high or low. Among them, high serum alkaline phosphatase values ​​are more common, such as abnormal liver function, kidney disease, and some tumor patients may also have high serum alkaline phosphatase values. The following will introduce in detail the reasons why serum alkaline phosphatase values ​​are high.

Serum alkaline phosphatase is mainly used for the examination of obstructive jaundice, primary liver cancer, secondary liver cancer, and cholestatic hepatitis. In patients with these diseases, liver cells overproduce ALP, which enters the blood through the lymphatic tract and hepatic sinusoids. At the same time, due to the obstruction of bile excretion in the intrahepatic bile duct, bile refluxes into the blood, causing a significant increase in serum alkaline phosphatase. However, serum alkaline phosphatase is also very active in bone tissue. Therefore, pregnant women, fracture healing period, and osteomalacia. Serum alkaline phosphatase may also be elevated in rickets, osteocellular carcinoma, osteoporosis, liver abscess, liver tuberculosis, cirrhosis, leukemia, and hyperthyroidism, and should be differentiated.

Normal serum alkaline phosphatase levels

The normal value range of serum alkaline phosphatase varies under different testing methods. Let's take a look at the normal values ​​of serum alkaline phosphatase using different test methods:

1. Enzyme rate method (37°C):

Adult: 40～160U/L;

Children: <350 U/L;

2. Disodium phenyl phosphate method:

Adults: 3-13 Kat units;

Children: 5-30 kat units;

3. Dynamic method: Adults: 20~110U/L;

teenager:

(1) Male: <750 U/L;

( 2) Female: <500 U/L;

Children: <500 U/L;

Infants: 50~240U/L.

Causes of elevated serum alkaline phosphatase include:

1. Causes of metabolic abnormalities

Alkali phosphatase is mainly used for the examination of obstructive jaundice, liver cancer, cholestatic hepatitis, etc. Obstructive jaundice, primary liver cancer, secondary liver cancer, and cholestatic hepatitis will cause alkaline phosphatase to be elevated.

2. Abnormal bile duct excretion

Alkaline phosphatase needs to pass through the liver and then be excreted through bile. When abnormalities occur in the excretion process, it will cause high serum alkaline phosphatase levels.

3. Bone tissue causes

Because this enzyme is also very active in bone tissue. Therefore, pregnant women, fracture healing period, and osteomalacia. Serum alkaline phosphatase will increase in rickets, osteocellular carcinoma, osteoporosis, etc.