Causes of Thrombotic Thrombocytopenic Purpura

Generally speaking, the occurrence of thrombotic thrombocytopenic purpura is closely related to the medications taken by the patient. The occurrence of thrombotic thrombocytopenic purpura will pose more threats to the patient's blood vessels and may also cause anemia.

Thrombotic thrombocytopenic purpura is also known as thrombotic microangiopathic hemolytic anemia, platelet thrombosis syndrome, etc. It is an uncommon thrombotic microangiopathy with microangiopathic hemolytic anemia. The clinical features include fever, thrombocytopenic purpura, microangiopathic lytic anemia, multiple nervous system injuries and renal damage. The cause of the disease is unknown, but it may be related to vascular factors, infection, and drug allergy. Most patients are between 10 and 40 years old, and about 60% are female. The onset is acute and the condition is serious. Two-thirds of cases die within three months. A few cases progress more slowly and the course of the disease can last from several months to several years.

Causes

About 90% of thrombotic thrombocytopenic purpura has no obvious cause or underlying disease. Some are secondary, mostly secondary to the following diseases:

(1) Drug allergy, such as penicillin, sulfonamides, iodine, chloroquine, aspirin, phenacetin, and oral contraceptives;

(2) Poisoning (CO, dyes, paint, etc.) and bee stings, dog bites, etc.;

(3) Immune diseases, such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, polyarteritis, and Sjögren's syndrome;

(4) Late pregnancy;

(5) Anti-tumor treatment: mitomycin, daunorubicin, cyclosporine A, injectable vaccines, etc.

(6) Certain infections, such as bacterial, rickettsial, viral and mycoplasma infections.