How many generations can pancreatic cancer be inherited

Pancreatic cancer is a highly malignant digestive tract tumor that is difficult to diagnose and treat. About 90% of them are ductal adenocarcinomas that originate from the glandular duct epithelium. Its morbidity and mortality have increased significantly in recent years. The 5-year survival rate is less than 1%, making it one of the malignant tumors with the worst prognosis. The early diagnosis rate of pancreatic cancer is not high, so how many generations will pancreatic cancer be inherited?

Pancreatic cancer can occur in multiple members of the same generation of a family, or in multiple members of several generations of a family. There was a family with three generations of pancreatic cancer, which may be the first example of a large number of familial pancreatic cancers.

However, the idea that pancreatic cancer is hereditary has not been widely accepted. Some epidemiologists have conducted research on the familial incidence of pancreatic cancer, and these studies have shown that the incidence of pancreatic cancer in people with a family history is 3-13 times higher than that in sporadic cases, and that pancreatic cancer tends to cluster in some families.