What anticancer drugs should I take for nasopharyngeal cancer

Nasopharyngeal carcinoma refers to a malignant tumor that occurs on the top and side walls of the nasopharyngeal cavity. It is one of the most common malignant tumors in my country, and its incidence rate ranks first among malignant tumors of the ear, nose and throat. Common clinical symptoms of nasopharyngeal carcinoma include nasal congestion, blood in mucus, stuffy ears, hearing loss, diplopia and headache. Nasopharyngeal carcinoma has obvious epidemiological characteristics. It is more common in men, about twice as common in women. It can occur in all age groups, mostly between 30 and 50 years old.

There are obvious regional differences in the distribution of nasopharyngeal carcinoma in China, with Zhaoqing, Foshan, Guangzhou in the central part of Guangdong Province and Wuzhou in the eastern part of Guangxi Province as the high-incidence centers, and gradually decreasing in the surrounding areas. Due to the hidden location of the nasopharynx and the complex early symptoms, it is easy to misdiagnose and miss the diagnosis. At the same time, nasopharyngeal carcinoma has the characteristics of metastasis to the cervical lymph nodes and cranial nerves when the primary cancer lesion is very small or not obvious.

Commonly used drugs for the treatment of nasopharyngeal carcinoma include nitrogen mustard, cyclophosphamide, 5-fluorouracil, bleomycin, thiotepa, etc. One drug can be used alone or in combination. Commonly used combined chemotherapy regimens are as follows:

(1) CBF regimen: 600-1000 mg of cyclophosphamide per intravenous injection; on the 14th day, 15 mg of bleomycin per intramuscular injection; on the 15th day, 500 mg of 5-fluorouracil per intravenous injection; on the 25th day, rest for one week after the end of the treatment; a total of 4 courses of treatment with an effective rate of 60.8%;.

(2) PFA regimen: 20 mg of cisplatin and 500 mg of 5-fluorouracil are intravenously dripped for 5 days; 40 mg of doxorubicin is intravenously injected on the first day of the treatment; repeated once every 3 to 4 weeks; it has a significant effect on shrinking the tumor.

(3) PF regimen: 20 mg/m2 cisplatin and 500 mg/m2 5-fluorouracil intravenous drip; use for 5 consecutive days followed by a 2-week break; 2 to 3 courses of this regimen; generally used to shrink tumors before radiotherapy or for cases of chemotherapy alone, with an effective rate of 93.7%;.

In addition, recent studies have shown that the anti-tumor mechanism of the Chinese medicine ginsenoside Rh2 is very extensive, mainly through regulating the proliferation cycle of tumor cells, inducing cancer cell differentiation and apoptosis to exert anti-tumor effects. It can inhibit the growth of nasopharyngeal cancer cells, reduce the volume of cancer tissue or eliminate the tumor.