Alanine aminotransferase and bilirubin are high

When we check liver function, we often test the levels of alanine aminotransferase and bilirubin, and judge the condition of the liver based on the conclusions. Some people find that their alanine aminotransferase levels are high after examination. There are many possible reasons, and we need to understand them one by one. Only after further examination can we know what is going on in the body. Let’s take a closer look below.

Causes of high alanine aminotransferase

There are many factors that can cause elevated alanine aminotransferase levels, such as acute hepatitis, taking medications (especially those that are harmful to the liver), long-term drinking or drinking a large dose at one time, certain biliary diseases, heart failure in heart disease, fever, and other diseases, all of which can cause elevated alanine aminotransferase levels.

Simply having elevated transaminase levels (abnormal liver function) does not confirm that you have hepatitis. To be sure that you have hepatitis, the following three points must be met at the same time. That is, there are symptoms and signs of hepatitis (such as low-grade fever, aversion to oil, nausea, vomiting, fatigue, poor appetite, swollen and painful liver, etc.) and clinical diagnosis (such as acute icteric type, chronic protracted type, etc.); increased serum transaminase; etiological diagnosis (the presence of anti-hepatitis A antibodies is type A, and the presence of positive hepatitis B virus surface antigen, e antigen and core antibody is type B). Some people simply have high transaminase levels, but it is possible that there are interferences due to factors such as excessive drinking, strenuous exercise, working night shifts, colds, or taking certain oral medications before the test.

Alanine aminotransferase is mainly found in the liver, heart and skeletal muscle. Damage or necrosis of liver cells or certain tissues will increase the level of alanine aminotransferase in the blood. There are many clinical diseases that can cause abnormal transaminase, which must be identified.

Causes of high bilirubin

1. Generally speaking, an increase in total bilirubin is caused by liver problems, such as acute or chronic icteric hepatitis, cirrhosis, or adverse reactions caused by blood type incompatibility during blood transfusion, or toxic hepatitis can also cause an increase in total bilirubin.

2. High bilirubin levels indirectly increase. Because the patient suffers from some hemolytic diseases, excessive damage to the red blood cells in the body will occur, causing an increase in total bilirubin. If there is a incompatibility between the blood types of the mother and the fetus during pregnancy, it will also lead to an increase in total bilirubin.

3. Direct increase in total bilirubin. If you suffer from cholelithiasis or liver cancer caused by obstruction of the bile duct, it will cause obstructive jaundice, which will directly lead to an increase in total bilirubin.