The role of cold precipitation

I don't know if you have heard of the treatment method of cryoprecipitation. This treatment method is generally used to treat hemophilia. Because many people with hemophilia are particularly prone to bleeding, a more effective treatment method to stop bleeding is cryoprecipitation, which coagulates the collagen in the blood. So what is the role of cryoprecipitation?

Cryoprecipitation (cryoprecipitation; cryoprecipitate; cryoprecitation) refers to plasma cryoprecipitate containing factor VIII and fibrinogen, which can treat patients with hemophilia or patients with bleeding due to lack of factor VIII and fibrinogen. The infusion should be completed within 6 hours after thawing, and the infusion rate should not be less than 200ml/h. It is suitable for children and adults with mild hemophilia A, von Willebrand disease, congenital or acquired fibrinogen deficiency and factor XⅢ deficiency. Sometimes cryoprecipitate is also used as an alternative treatment for patients with postoperative bleeding, severe trauma and DIC.

Indications

1. Congenital or acquired fibrinogen deficiency: For fibrinogen deficiency caused by severe trauma, burns, leukemia and liver failure, infusion of cryoprecipitate can significantly improve the prognosis.

2. Congenital or acquired coagulation factor VIII deficiency: Since cryoprecipitate contains a relatively rich amount of FVIII, it is often used as a substitute for FVIII concentrate.

3. Von Willebrand disease (vWD): Von Willebrand disease is characterized by a lack or defect of vWF in plasma. Because cryoprecipitate contains high levels of FⅧ and vWF, cryoprecipitate is the most ideal preparation for vWD replacement therapy.

4. Children and mild adults with hemophilia A: The treatment of hemophilia A mainly relies on FVIII supplementation. Cryoprecipitate is one of the most effective preparations besides FVIII concentrate.

5. Cold precipitate contains fibronectin (Fn), which can make the wound heal quickly and smoothly when infused after surgery.

6. Hypovolemic shock complicated by DIC.