The bumps and scratches that happen in life always catch people off guard. In severe cases, the patient will need to go to the hospital for wound sutures, and the wound will take a long time to heal. Moreover, various reasons, such as wound infection, inflammation, etc., may make it difficult for the wound to heal for a long time, especially foot injuries. Some people's foot wounds do not heal for a long time, which affects their normal walking and brings many inconveniences to their life and work. What is the reason for this situation? Causes of long-term wound healing There are many reasons for the long-term non-healing of wounds, among which wound infection, excessive wound damage area, fat liquefaction in the wound area, foreign matter in the wound, age factors, the patient's nutritional status, and the patient's physical condition are all the main reasons for the long-term non-healing of wounds. 1. Bacterial load and wound infection are important causes of wound non-healing. Wound infection is the most serious interfering factor in the wound healing process, which mainly manifests itself in destroying the remaining epithelial tissue and delaying the healing time. When sepsis occurs, epithelial growth can stop. 2. Inflammatory response is the basis of wound healing, but excessive inflammatory response will cause necrosis of local tissue cells. Necrotic tissue is a factor that hinders wound healing. If it is not controlled in time, it may also lead to systemic infection, which will aggravate the difficulty of wound healing and even be life-threatening. 3. Malnutrition or lack of certain nutrients may cause wounds to not heal. Nutritional status The quality of nutritional status will directly or indirectly affect wound healing. For example, protein deficiency can slow down the formation of new blood vessels, fibroblast proliferation and collagen synthesis; at the same time, it can affect the phagocytic function of cells, reduce immunity, slow down tissue repair, and make wounds difficult to heal. 4. Certain systemic diseases can cause wounds to not heal. 5. Direct use of antibiotics in wounds may cause the wound to not heal. In order to fight infection, the use of antibiotics in wounds is common in clinical practice. In fact, local application of antibiotics can easily produce drug-resistant strains, and the concentration of antibiotics is highest on the surface of the wound and gradually decreases deep in the wound, which cannot achieve the antibacterial effect and is more likely to produce drug resistance. 6. The patient’s mental state may also be a reason for wound failure to heal. Long-term social factors such as depression, tension, and anxiety can indirectly affect wound healing by damaging the body's immune function through the neuroendocrine system. 7. Aging can lead to delayed wound healing The regenerative capacity of tissue cells at different ages is different, and generally the tissue regeneration capacity decreases with age. In addition, the elderly are prone to hardening of blood vessels, which reduces local blood supply, and the division and proliferation cycle of fibroblasts is significantly prolonged, and cell activity is generally reduced, resulting in delayed wound healing, decreased healing quality, and even non-healing. |
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