Does sildenafil tablets have any side effects?

In life, many people are often troubled by some diseases. There are many reasons why people suffer from diseases. No matter what the disease is, there are many drugs used to treat the disease. For the wide variety of drugs, when using them to treat diseases, you must make the right choice, because as long as it is a drug, it has certain side effects. Sildenafil tablets also have certain side effects during treatment.

Side effects of sildenafil tablets

1. Sildenafil tablets do have side effects, such as common side effects such as headache, facial flushing, and indigestion, but they are generally not serious and disappear quickly. Less common side effects include temporary changes in color vision (such as inability to distinguish between blue and green objects or a blue tint to such objects), increased sensitivity to light, and blurred vision.

2.Sildenafil tablets are oral medications for the treatment of erectile dysfunction. It is the citrate salt of sildenafil, a cyclic guanosine monophosphate (cGMP)-specific 5

Selective inhibitor of phosphodiesterase type 5 (PDE5). In the event of overdose, routine supportive care should be instituted as needed. Because sildenafil is highly bound to plasma proteins and is not cleared in the urine, renal dialysis will not increase its clearance rate.

3. For most patients, the recommended initial dose of sildenafil tablets is 50 mg, taken about 1 hour before sexual activity; but 0.5 to 1 hour before sexual activity

Can be taken at any time within 4 hours. Based on efficacy and tolerability, the dose may be increased to 100 mg (maximum recommended dose) or decreased to 25 mg. Take no more than once daily.

Effects of sildenafil tablets

1. Sildenafil tablets are suitable for the treatment of erectile dysfunction. For most patients, the recommended dose is 50 mg, taken on demand about 1 hour before sexual activity, but can be taken at any time within 0.5-4 hours before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg (maximum recommended dose) or decreased to 25 mg. Take no more than once daily. In the absence of sexual stimulation, sildenafil at recommended doses is ineffective.

2. The following factors were associated with increased plasma sildenafil levels (AUC): age over 65 years (increased by 40%), liver damage (such as cirrhosis, increased by 80%), severe renal impairment (creatinine clearance [30

ml/min, increased by 100%), and taking potent cytochrome P4503A4 inhibitors [ketoconazole, itraconazole (increased by 200%), erythromycin (increased by 182%), saquinavir (increased by 210%) at the same time. Because higher plasma levels may increase both efficacy and the incidence of adverse events, a starting dose of 25 mg is appropriate for these patients.

3. A study conducted in healthy subjects without HIV infection showed that Ritonavir can significantly increase the blood level of sildenafil. In view of this, it is recommended that patients taking ritonavir at the same time should not take more than 25 mg per 48 hours.

4. Sildenafil can enhance the antihypertensive effect of nitrates, so patients taking any dosage form of nitric oxide donors and nitrates should not take sildenafil.

5. When sildenafil needs to be used in combination with α-receptor blockers, the patient should have achieved a stable state with α-receptor blocker treatment before sildenafil treatment, and sildenafil should be started at the lowest dose.