The desensitization injection steps need to start from these three aspects

Because of the disease, many people need desensitization injections. This technology can help asthma patients easily relieve symptoms and prevent some allergic asthma diseases. However, desensitization injections need to be divided into steps in treatment. There are usually three methods: desensitization through injection, sublingual administration, etc. These methods are very effective and can quickly stabilize the patient's condition and prevent worsening of the disease.

Treatment

Specific desensitization therapy

Specific desensitization therapy is one of the treatments currently used for allergic diseases such as asthma. After determining the allergens that cause allergic reactions in patients, the allergens are made into extracts of various concentrations, which are repeatedly injected into the patients or repeatedly contacted with the patients through other means. The dosage increases from small to large, and the concentration increases from low to high, in order to improve the patient's tolerance to such specific allergic substances, which can play a certain preventive and therapeutic role. But it is applicable to extrinsic asthma, and the allergens must also be clearly identified. You must persist for 2 to 3 years or longer. Most patients are allergic to many substances, and these substances cannot all be made into extracts for injection. Different physiques react differently to these extracts, and the therapeutic effects are also inconsistent. It must be done under the guidance of a doctor.

Desensitization therapy is currently the only effective means of treating allergic diseases. Once the allergen is confirmed, contact cannot be avoided and conventional treatments fail to achieve the desired results, so it is necessary to conduct standardized causal desensitization treatment. Desensitization therapy is to prepare allergens into medicines, so that patients can gradually adapt to the allergens after use until antibodies are produced. When the patient comes into contact with the substance again, it will not induce an allergic reaction in the body, and the symptoms caused by the allergy will disappear or be significantly alleviated.

There are three commonly used methods :

Injection desensitization therapy

Allergen injection desensitization therapy involves intradermal injection of allergen extracts. Desensitization injections start with a small dose and gradually increase the dose to increase tolerance to the allergen. Desensitization treatment generally takes at least 2 to 3 years, and long-term injections will cause certain pain.

Sublingual desensitization therapy

Sublingual desensitization therapy is to make allergy-inducing substances (such as dust mite active proteins) into desensitizing solutions of different concentrations, and administer them daily in a small dose that the patient can adapt to (drop the desensitization drops under the tongue, allow it to be slowly absorbed, and swallow it after 1 to 3 minutes). The dose is gradually increased, and after reaching the maintenance level, it is continued for a sufficient period of time to improve the patient's tolerance.

Sublingual desensitization therapy has been confirmed to be effective and has been recognized by the World Health Organization. It has been vigorously promoted in developed countries such as Europe and the United States. The outstanding advantage of sublingual desensitization therapy is that it is easy to use. Patients can take it themselves at home, avoiding the pain and fear caused by injections, and it is safer. my country has also adopted this therapy. We have standardized sublingual desensitization drugs for dust mites drops in the country, which are effective and have greatly improved the quality of life of allergy patients.

Desensitization therapy generally takes 3 to 6 months to take effect. To maintain long-term efficacy, the medication should be continued for a period of time after the symptoms disappear. Generally, 2 years is recommended. The efficacy can last for many years, or even for life. Allergic rhinitis, allergic asthma, allergic conjunctivitis, allergic rash caused by dust mites. The patient's immunological indicators also changed before and after sublingual dust mite immunotherapy. Because the sublingual mucosal tissue is thin, these Langerhans cells located on the mucosal surface will capture the signal of the presence of allergens when they come into contact with antigens. The allergen vaccine can be quickly absorbed, thereby initiating a desensitization reaction. Including increased serum IgG4 levels and improved Th2/Th1 cell ratio. Since the drug is administered sublingually, serious adverse reactions such as anaphylactic shock usually do not occur. A very small number of patients may occasionally experience mild rash or mild diarrhea, which can be recovered by stopping treatment or reducing the dosage. The mechanism of sublingual desensitization therapy is that there are a large number of Langerhans cells in the sublingual mucosa, which absorb trace amounts of dust mite allergens and process them into mite polypeptide information, which are then presented to Th0 cells, causing the Th0 cells to transform into Th1 cells, thereby preventing the occurrence of allergic reactions.