In the medical world, there are many drugs that we have never seen. These drugs are occasionally seen in the list of drugs used or found in the list of drugs and additives, so many people do not pay attention to them. As a result, when using them, they cause side effects to the body without paying attention. The main function of iodine is to adjust body functions, but excessive consumption can cause premature beats, accelerated heartbeat, and may even cause some complications. Be sure to understand it carefully before using iodine. What are the side effects of amiodarone? Amiodarone (ethylamiodarone, amiodarone) is a derivative of benzofuran and belongs to Class III antiarrhythmic preparations. It was originally a drug for treating angina pectoris and is still used for angina pectoris today. In recent years, it has been widely used in the clinic to treat arrhythmias with good results, especially it is best effective in terminating and preventing various types of supraventricular and ventricular arrhythmias. Its electrophysiological effect can prolong the action potential interval of the atrial and ventricular muscles without changing the resting membrane potential, which actually delays the repolarization process; its direct cell membrane effect and anti-sympathetic nerve effect can curb the excitability of the atrial and ventricular muscles, and have an anti-ventricular fibrillation effect. Amiodarone has significant effects on ventricular premature beats, ventricular tachycardia, prevention of ventricular fibrillation, and control of refractory rapid arrhythmias, and it also has a good effect on fatal ventricular arrhythmias. In addition, amiodarone can correct atrial flutter and atrial fibrillation and restore the heart to sinus rhythm. Since amiodarone has a significant effect of dilating coronary arteries, it is a good indication when coronary heart disease is accompanied by the above-mentioned arrhythmias. The only drawback is that the incidence of side effects of amiodarone is quite high and severe, but we should not refuse to use this drug just because of fear of choking. As long as we understand its side effects, pay attention to being vigilant and observing closely during the application process, and pay great attention to its adverse reactions, it can be used. Its side effects are introduced as follows: Pulmonary Side Effects Early symptoms of pulmonary toxicity from this drug include dyspnea on exertion, dry cough, fatigue, and weight loss. There are also symptoms such as low fever, pleural pain, and muscle weakness, but they are rare. It has been reported that one-third of cases of pulmonary toxicity caused by amiodarone occurred in people over the age of 60. Adverse reactions to the eyes Among antiarrhythmic drugs, amiodarone is the only drug that has side effects on the eyes. Its adverse reaction is the deposition of microparticles on the cornea. These microparticles are composed of yellow-brown pigments. This lysosome-like lipofuscin is deposited on the inner wall of the cornea and usually disappears gradually 17 months after stopping the drug. Inducing and aggravating arrhythmias Amiodarone, like other antiarrhythmic drugs, can induce and aggravate arrhythmias. Experts point out that it can cause fatal arrhythmias and ventricular fibrillation and ventricular tachycardia. Elderly patients with hypotension and reduced myocardial function may be very sensitive to the blood pressure-lowering effect of amiodarone. Some patients may experience low blood pressure after taking amiodarone for 5 to 10 days, especially intravenous injection of this product can cause severe hypotension. Thyroid dysfunction (hypothyroidism or hyperthyroidism) The toxic and side effects of this drug can damage thyroid function and cause thyroid dysfunction. All patients taking amiodarone have varying degrees of changes in thyroid function. The average thyroxine level and free thyroxine index were approximately 20% higher than normal, while the free binding amount was slightly reduced. For most patients with thyroid dysfunction, symptoms will disappear on their own 1 to 2 months after stopping the medication. Constipation: The side effect of amiodarone causing constipation cannot be ignored, especially for the elderly with coronary heart disease and arrhythmia. Constipation often aggravates coronary heart disease and arrhythmia. In addition, the side effects of this drug include nausea, vomiting, sinus bradycardia, atrioventricular block, etc. |
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