What is the bone marrow transplant process like?

Bone marrow transplantation is highly recommended by many people as a common treatment method because of its high chance of alleviating or curing symptoms. It is also a method often used by doctors when dealing with difficult and complicated diseases. At the same time, high requirements are placed on the bodies of both the transplant recipient and the transplant recipient to avoid serious consequences. So, what is the bone marrow transplant process?

Necessary transplant examinations are performed to assess the overall condition to ensure the safety of subsequent transplantation and provide a reference for future evaluations. Bone marrow or stem cell collection. Stem cells can be collected from the donor's bone marrow or peripheral blood. If an autologous transplant is performed, stem cell mobilization and collection should be performed in advance.

Before transplantation, patients undergo a course of high-dose chemotherapy and/or radiation therapy, called conditioning. The purpose of pretreatment is to remove abnormal cells such as tumor cells in the body. If it is an allogeneic transplant, the process of mobilizing and collecting donor bone marrow or peripheral blood stem cells is carried out simultaneously with the transplant pretreatment process.

In a transplant, previously collected, frozen or freshly collected (from an allogeneic donor) bone marrow or peripheral blood stem cells are given into your body through a vein as quickly as possible. Once these stem cells enter the peripheral blood and migrate to the bone marrow, they begin to produce large numbers of blood cells.

The earliest manifestation of implantation is an increase in peripheral blood leukocytes. During this stage, the number of leukocytes, especially neutrophils, is frequently tested to observe the effect of implantation. When the white blood cell count reaches a certain level, it can resist infection and some other complications, and the blood picture begins to return to normal. Once the patient has fully recovered, he or she can be discharged from the hospital.

Bone marrow transplantation is the fundamental treatment for various blood tumors, aplastic anemia, severe thalassemia, and some congenital immune deficiencies or metabolic diseases.