Serum lactate dehydrogenase is high, and it is caused by these reasons

If the serum lactate dehydrogenase level is high during the examination, it means that there is something wrong with the physical condition. The patient may suffer from liver disease, lung disease, heart disease, kidney disease, muscular dystrophy and other diseases. If the serum lactate dehydrogenase level is low, it is largely caused by overwork, and the patient will recover after timely conditioning.

1. What causes high serum lactate dehydrogenase?

1. Liver disease. When the liver is diseased and liver cells are damaged, LDH4 and LDH5 in the blood will increase significantly. LDH5/LDH4<1 often indicates primary liver cancer. In acute hepatitis, LDH5 increases significantly, while LDH4 does not increase. Chronic hepatitis is manifested by a continuous increase in LDH5, or a decrease and then an increase.

2. Lung disease. Serum LDH3 often increases in lung diseases. In patients with lung abscess, serum LDH3 and LDH4 are often elevated simultaneously with LDH5.

3. Heart disease. Serum LDH1 and LDH2 are significantly elevated in viral and rheumatic myocarditis, Keshan disease myocardial damage, and acute myocardial infarction.

4. Kidney disease. Serum LDH5 may increase in acute tubular necrosis, chronic glomerulonephritis and renal transplant rejection.

5. Muscular dystrophy of muscle tissue. The levels of LDH4 and LDH5 in the patients' blood were significantly elevated.

There are many reasons for high lactate dehydrogenase levels. Therefore, if you want to know which cause of the high lactate dehydrogenase level, you need to make a comprehensive judgment based on the test results.

2. Reasons for low lactate dehydrogenase:

Lactate dehydrogenase is present in the cytoplasm of all tissue cells in the body, with the highest content in the kidneys. The normal range of serum lactate dehydrogenase is 100~300U/L. When lactate dehydrogenase is low, the common causes are as follows.

1. Errors occurred during the inspection process.

2. Endocrine disorders.

3. Overwork, poor sleep, bad mood, etc.

In short, low lactate dehydrogenase is generally not very serious and can be restored through conditioning. However, if lactate dehydrogenase is too high, it should be taken seriously. Pulmonary infarction, pernicious anemia, shock and pleural effusion caused by tumor metastasis can cause elevated levels of lactate dehydrogenase.