What is antiphospholipid antibody syndrome

There are various diseases in life, some of which we may be very familiar with, such as colds, fevers and other diseases. But some of them are completely unfamiliar to us and we have never heard of their names. Just like when it comes to the disease of antiphospholipid antibody syndrome, many people are confused, let alone being able to make timely judgments and treatment when they encounter it. So the editor would like to introduce to you what antiphospholipid antibody syndrome is?

1 Antiphospholipid syndrome (APS) is a general term for a group of clinical signs caused by antiphospholipid antibodies (APL antibodies). APL antibodies are a group of antibodies that can react immune to a variety of antigenic substances containing phospholipid structures, mainly including lupus anti-coagulant (LA), anti-cardiolipid antibody (ACL antibody), anti-phosphatidic acid antibody and anti-phosphatidylserine antibody. The clinical manifestations associated with APL antibodies mainly include thrombosis, habitual abortion, thrombocytopenia and neuropsychiatric symptoms. APS is a common clinical manifestation in SLE patients.

2 Antiphospholipid antibodies refer to lupus anti-coagulant (LA), anti-cardiolipid antibody (ACL) or a group of autoantibodies against other phospholipids or phospholipid complexes. The cause of antiphospholipid antibodies is still unclear. Immunization of animals with bacteria can induce the production of antiphospholipid antibodies, indicating that infectious factors may play a certain role. In addition, it may also be related to genetic factors. Studies have reported that the frequencies of HLA-DR7 and DR4 increase in patients with antiphospholipid antibody syndrome, and the frequency of HLA-DR53 is higher in those who are positive for antiphospholipid antibodies.

The most basic pathological feature of antiphospholipid antibody syndrome is thrombosis and all clinical manifestations are related to it. It was previously believed that antiphospholipid antibodies only target negatively charged phospholipids. It is now discovered that antiphospholipid antibodies may act more directly on one or more plasma proteins bound to phospholipids or the complexes of these proteins and phospholipids, the most important of which are β2-glycoprotein Ⅰ (β2-GPⅠ) and prothrombin.

Antiphospholipid antibody syndrome is a general term for a group of clinical signs caused by antiphospholipid antibodies. APL antibodies are a group of antibodies that can react immune to a variety of antigenic substances containing phospholipid structures, mainly including lupus anticoagulant, anti-cardiolipin antibodies, anti-phosphatidic acid antibodies and anti-phosphatidylserine antibodies. The clinical manifestations associated with APL antibodies mainly include thrombosis, habitual abortion, thrombocytopenia and neuropsychiatric symptoms. APS is a common clinical manifestation in SLE patients.

The above content is an analysis of the disease of antiphospholipid antibody syndrome from a professional perspective. At the same time, we would like to remind everyone that if you find that someone around you has this disease, you must not panic. Timely hospital examination and diagnosis is the key, and early treatment is also the basis for a speedy recovery.