What is the liver function test

Now the importance of physical examinations is gradually emerging. Many people are more concerned about what liver function tests are included in the physical examination. Liver function is mainly some common clinical examination items in life, and it is also relatively common in life. At the same time, many people will choose some treatment methods when they find that they have liver diseases. Before facing the treatment methods, they will choose liver function tests, which is also a common treatment method for diagnosing liver diseases, and it is also a relatively common examination method in life.

Liver function tests are also a relatively common type of test. Many patients do not know much about liver function tests, but liver function tests do have certain clinical significance and are critical to the prevention, treatment and treatment of liver disease. Below we briefly introduce what liver function tests test.

(1) Indicators reflecting liver parenchymal damage

It mainly includes alanine aminotransferase (ALT), aspartate aminotransferase (AST), etc. Among them, ALT is the most commonly used sensitive indicator. When 1% of liver cells are necrotic, the serum ALT level can increase by 1 times. Continuous increase in AST and values ​​exceeding ALT often indicate severe liver parenchymal damage and is a sign of increasing chronicity.

(2) Indicators reflecting bilirubin metabolism and cholestasis

It mainly includes total bilirubin (TBil), direct and indirect bilirubin, urinary bilirubin, urobilinogen, blood bile acid (TBA), γ-glutamyl transpeptidase (γ-GT) and alkaline phosphatase (ALP). The above indicators may increase when there is hepatocyte degeneration and necrosis, bilirubin metabolism disorder or intrahepatic cholestasis. In hemolytic jaundice, elevated indirect bilirubin may occur.

(3) Indicators reflecting liver synthesis function

It mainly includes albumin, prealbumin, cholesterol lipase, prothrombin time and activity, etc. When albumin and cholesterol lipase are reduced for a long time and prothrombin activity decreases, and vitamin K supplementation cannot correct the situation, it means that normal liver cells are gradually decreasing, the liver cells have poor function in synthesizing proteins and coagulation factors, the liver reserve function is reduced, and the prognosis is poor.

(4) Indicators reflecting liver fibrosis

It mainly includes type III procollagen (PⅢP), type IV collagen hyaluronic acid (HA), laminin (LN), etc. These indicators can assist in the diagnosis of liver fibrosis and early cirrhosis.

(5) Detection indicators of liver coagulation function

The liver can synthesize all coagulation factors except factor III and factor a chain, and plays an important role in maintaining normal coagulation function. Patients with liver disease have reduced synthesis of coagulation factors, and clinically they may experience bleeding from the gums and nasal mucosa, ecchymosis of the skin, and in severe cases,

Gastrointestinal bleeding is present. Generally, factor VII appears first and decreases the most, followed by factors II and X, and factor V appears last and decreases the least.

The above is what liver function tests check. Liver function tests are mainly used to prevent and treat diseases based on some changes in the liver. They mainly check the substantial damage indicator of liver function, bilirubin. As well as some bile metabolism, liver fibrosis indicators and liver coagulation function test indicators, to treat and correctly diagnose liver diseases based on whether the indicators are normal