Is radionuclide treatment for nasopharyngeal carcinoma bone metastasis effective?

Is radionuclide therapy good for nasopharyngeal carcinoma bone metastasis? What is the effect?

1. Patients with nasopharyngeal carcinoma may experience nasal congestion, ear closure, tinnitus, numbness of the neck, diplopia, and sagging of the upper and lower cervix. It often occurs in the pharyngeal recess and the anterior wall of the nasopharynx. During examination, the neck mass is usually hard, with a small nodular surface, and is difficult to move because of adhesions with the surrounding area. Sometimes they fuse together to form a huge mass on the entire side of the neck.

2. At present, radiotherapy is still the first choice of treatment. Nasopharyngeal carcinoma is sensitive to radiation. The primary lesion of nasopharyngeal carcinoma and the cervical lymph node drainage area can be included in the irradiation field. The 5-year survival rate of radiotherapy for nasopharyngeal carcinoma at all stages is about 50%. Bone metastasis can be relieved of symptoms, relieve bone pain, and control metastasis after radiotherapy. If necessary, radionuclide therapy, pamidronate disodium, can also delay the destruction of the old substance.

3. Treatment of bone metastasis of nasopharyngeal carcinoma: More than 95% of nasopharyngeal carcinomas are poorly differentiated and undifferentiated types, which are highly malignant, grow rapidly, and are prone to lymph node or blood metastasis.

4. When nasopharyngeal carcinoma is diagnosed, 75% of patients are already in stage III and IV. The later the stage of the disease, the more chances of distant metastasis and the worse the prognosis. Radiotherapy is a local treatment method that cannot prevent distant metastasis. Therefore, combined use of chemicals or combined treatment of several drugs may shrink the tumor or eliminate tiny lesions and improve the treatment effect.