What are the symptoms of liver cancer patients in the middle stage? 6 most common symptoms of liver cancer in the middle stage

The symptoms of mid-stage liver cancer are between the early and late stages, and generally there are no obvious symptoms. Patients with symptoms who seek medical treatment on their own are mostly in the mid-to-late stages, often with symptoms such as pain in the liver area, loss of appetite, fatigue, weight loss, and liver enlargement. The main characteristics of mid-stage liver cancer symptoms are as follows:

1. Pain in the liver area Patients with more than 100% of the cases have pain in the liver area. The pain is equivalent to the location of the tumor, and it is often persistent or dull. Liver pain is caused by the rapid growth of the tumor, which pulls the liver capsule. If the lesion invades the diaphragm, the pain may involve the right shoulder. When the cancerous nodule ruptures, it may suddenly cause severe pain and symptoms and signs of peritonitis. If the amount of bleeding is large, it may cause syncope and shock.

2. Liver enlargement: About 90% of patients have enlarged livers, which are progressive and hard in texture. They are uneven, with nodules or lumps of varying sizes, blunt and irregular edges, and often with varying degrees of tenderness. When liver cancer protrudes under the right costal arch or xiphoid process, the upper abdomen may show local bulge or fullness. If the tumor is located on the diaphragmatic surface, the main manifestation is that the diaphragm is elevated and the lower edge of the liver may not be enlarged. Because the arteries of liver cancer are rich and tortuous, or because the huge tumor compresses the hepatic artery or abdominal aorta, the inner diameter of the artery suddenly narrows, and sometimes a blowing-like vascular murmur can be heard on the abdominal wall close to the tumor.

3. Jaundice usually appears in the late stage and may be caused by liver cell damage, or by compression or invasion of the bile duct near the liver porta hepatis by the cancer mass, or by bile duct obstruction caused by the detachment of cancer tissue and blood clots.

4. Signs of cirrhosis Liver cancer patients with portal hypertension may have splenomegaly, ascites, and venous collateral circulation. The ascites increases rapidly and is usually transudate. Bloody ascites is often caused by cancer invading the liver capsule or rupturing into the abdominal cavity, and occasionally by peritoneal metastasis.

5. Systemic manifestations of malignant tumors include progressive weight loss, fever, loss of appetite, fatigue, malnutrition and cachexia. A small number of patients with liver disease may have special systemic manifestations, called paraneoplastic syndrome, with hypoglycemia and polycythemia being the most common, and other rare ones include hypercalcemia, hyperlipidemia, carcinoid, etc.

6. Symptoms of metastatic lesions If metastasis occurs to the lungs, bones, chest cavity, etc., corresponding symptoms may occur. Chest cavity metastasis is more common on the right side, and there may be signs of pleural effusion. Bone or spinal metastasis may cause local tenderness or nerve compression symptoms, and intracranial metastatic cancer may have nerve localization signs.