What is the treatment plan for osteosarcoma

The treatment of osteosarcoma is a comprehensive treatment with surgery as the main method. Chemotherapy greatly improves the survival rate by inhibiting the occurrence of lung metastasis, and chemotherapy greatly increases the chance of limb-saving surgery without the need for amputation. For typical osteosarcoma, if the preoperative chemotherapy is effective, extensive large-block resection can be performed. However, if chemotherapy is ineffective, radical resection or amputation should be performed. What are the treatment options for osteosarcoma?

Lung metastases are often treatable by resection.

1. Biopsy: Only with a clear histological diagnosis can the treatment plan be determined. Preoperative biopsy is very important and is part of surgical treatment. It should be performed by experienced doctors, because inappropriate biopsy can lose the opportunity to preserve the limb. Needle aspiration biopsy has the advantages of little pollution and low risk. Its diagnostic positive rate can be as high as more than 80% in experienced hospitals. If needle aspiration biopsy fails, an incisional biopsy should be performed as soon as possible. The incision for incisional biopsy is usually longitudinal and can be removed together with the tumor during surgery.

2. Chemotherapy is an important adjuvant treatment for osteosarcoma. High-dose chemotherapy combined with multiple drugs can kill local tumors. Preoperative chemotherapy (neoadjuvant chemotherapy) can cause tumor cell necrosis, tumor shrinkage, disappearance of edema in the reaction area and new tumor blood vessels, and clearer tumor calcification boundaries. Clinically, the patient's pain is relieved or disappears, the tumor becomes smaller, the joint range of motion increases, and AKP can be reduced to normal. High-dose chemotherapy is also an effective method for systemic treatment of osteosarcoma. Chemotherapy can kill micro-metastases in the lungs and the whole body. This treatment should be performed early. Micro-lesions are more sensitive to chemotherapy than large tumors. Adjuvant chemotherapy can reduce the number of tumors in the lungs and delay their appearance. The key to prolonging the survival of patients with lung metastasis is to completely remove the metastasis. Chemotherapy can promote the radical cure of the entire disease and increase the cure rate. Twenty to forty percent of patients abroad can be cured through multiple treatments.

If neoadjuvant chemotherapy cannot achieve tumor necrosis, delaying surgical treatment will affect the survival rate. Because when chemotherapy is ineffective, the tumor will continue to reproduce and microscopic lesions in the lungs will develop. When chemotherapy is effective, delaying radical surgery for the tumor will not jeopardize the survival rate. Preoperative chemotherapy can increase the success rate of limb salvage, so preoperative chemotherapy is safe and beneficial for patients preparing for limb salvage. The effect of preoperative chemotherapy can predict the cure rate. The successful implementation of chemotherapy has enabled osteosarcoma patients to not only improve their survival rate, but also retain their limbs and have a certain degree of joint function.

The above is the treatment plan for osteosarcoma. Regardless of whether surgery, radiotherapy or chemotherapy is performed for malignant tumors, you should take medicine (Chinese medicine) and combine Chinese and Western medicine. This is certain. We always say "combining Chinese and Western medicine". When encountering such a serious disease, it is time to combine Chinese and Western medicine. Comprehensive treatment should be used instead of using only one method.