Can I get pregnant after four chemotherapy sessions for endometrial cancer

With the worsening of pollution and the increase of social pressure, the number of women suffering from cancer has gradually increased, and the health of our female compatriots has been seriously threatened. The high-risk population is usually working people, and negative emotions and psychological burdens have become accomplices of cancer. Endometrial cancer is one of the common cancers in women. This disease not only harms health, but also deprives many women of the right to get pregnant. So how can we leave a glimmer of hope for the next generation when we are sick?

Endometrial cancer is a common gynecological malignancy, with about 5% of cases occurring in women of childbearing age under 40 years old. The main treatment is total hysterectomy with bilateral salpingo-oophorectomy or simultaneous retroperitoneal lymph node resection. However, as women around the world prepare for pregnancy later and later and people's requirements for quality of life increase, the treatment of young endometrial cancer patients should not only aim to reduce recurrence and prolong survival time, but also maximize the quality of life, preserve physiological function, or even preserve reproductive function while ensuring prognosis.

Generally speaking, endometrial cancer is a malignant tumor that occurs in the endometrium. However, as the disease progresses, the tumor will gradually invade the muscle layer, and metastasis may begin at that time! Lack of personal hygiene, sexual intercourse during menstruation, and heterosexual intercourse with people with sexually transmitted diseases are also prone to this disease. Elderly women have a decrease in estrogen levels, decreased vaginal acidity, and reduced cervical mucus plugs. Local inflammatory cell infiltration and exudation of inflammatory mediators show embryotoxic effects, which are not conducive to sperm survival and fertilized egg implantation. Inflammation involving the fallopian tubes can cause obstructive infertility.

After childbirth, abortion and various uterine cavity operations, this barrier function weakens or even disappears, which can easily lead to bacterial invasion and cause endometrial cancer. Once endometrial cancer occurs, the above functions will be out of balance, resulting in menstrual disorders and infertility. It can even cause symptoms such as vaginitis in women. Mild endometrial cancer is limited to the endometrial layer, while chronic or persistent infections often involve the fallopian tubes, which can easily lead to adnexitis.

The prerequisite for preserving the uterus for future pregnancy is that the endometrial cancer must be highly differentiated in pathological examination and without any evidence of myometrial invasion. At the same time, the patient must be young, infertile and willing to be closely followed up for observation.

For patients who want to preserve pregnancy, the following strategies are usually used:

1. First, give a large dose of progesterone treatment, the treatment dose is equivalent to more than 100 times the contraceptive dose. Endometrial biopsy should be performed three months after treatment. If the pathological results confirm that the lesion has improved, it should be used for another three months, followed by assisted pregnancy;

2. If the pathological results three months after treatment indicate that the lesion has not changed, endometrial biopsy will be performed for another three months. If the pathology shows improvement at that time, progesterone can continue to be used for three months, followed by another pathological examination. If the pathological results do not show that the endometrium has been transformed into a normal one, the pregnancy function should be abandoned immediately; if the pathological endometrium has been transformed into a normal endometrium, assisted pregnancy will be started.

Although there is hope for successful pregnancy in endometrial cancer, medicine still needs to be improved. Since endometrial cancer has many hazards, some issues have not yet been resolved, including the safety and success rate of fertility treatment, the possibility of ovarian tumors even if the pregnancy function is preserved, and whether hormone replacement is needed for postmenopausal women. With the continuous progress of medicine, these issues will be gradually improved.