The first choice drug for treating colorectal cancer

Many colorectal cancer patients have this question: There are many treatment methods, but what is the chemotherapy for colorectal cancer? Cancer treatment experts from the Oncology Hospital will introduce it to you.

After radical resection of colorectal cancer, about 50% of cases still have recurrence and metastasis, mainly because the hidden metastatic lesions were not discovered before surgery or the lesions were not completely removed during surgery. Therefore, before laparotomy, intra-intestinal chemotherapy for tumors or preoperative enema for rectal cancer can prevent the spread of cancer cells and kill and eliminate cancer cells. Continuing chemotherapy after surgery may increase the 5-year survival rate after radical resection.

5-fluorouracil is the first choice for chemotherapy of colorectal cancer. It is usually given by intravenous injection, 12-15 mg/kg, once a day for 5 days, then the dose is halved, once every other day, until obvious toxic symptoms such as vomiting and diarrhea appear, and the total amount reaches 8-10g for a course of treatment. This method has a slightly milder reaction and is suitable for outpatient treatment. For patients with liver metastasis, 150-300 mg of 5-fluorouracil can be given daily, orally in divided doses, with a total amount of about 10-15g, which is less effective than intravenous medication. Currently, most people advocate combined chemotherapy, but there is no mature plan. Some people suggest the MFC plan, that is, 5-fluorouracil 500 mg, mitomycin 4 mg, cytarabine 50 mg, combined application, intravenous injection twice a week in the first 1-2 weeks, and once a week thereafter, for a total of 8-10 times as a course of treatment. In addition to gastrointestinal reactions, the toxic symptoms of chemotherapy can also be seen in bone marrow suppression, which must be closely observed. In addition, commonly used chemotherapy drugs include furanfluorouracil, eufotaxime, cyclophosphamide, nitromethamine, nitromethamine and methylnitrosourea.