Is it necessary to have a blood test to check for skin cancer?

Skin cancer is a common disease among Caucasians, but there are also skin cancer patients in my country. If this disease can be detected in time, it can increase the patient's chance of survival. So is a blood test required to check for skin cancer? In order to enable everyone to detect skin cancer in time and treat it in time, it is very important to understand the examination items for skin cancer. The following is a detailed introduction to the examination items for skin cancer.

Biopsy pathological examination is also extremely important for the classification and treatment of skin cancer, and the treatment effects are also different.

Common examinations for skin cancer include physical examination, routine blood test, immune function test, pathological examination, X-ray examination, B-ultrasound examination, CT examination, radionuclide examination, etc.

Skin cancer includes basal cell carcinoma, squamous cell carcinoma, malignant melanoma, malignant lymphoma, idiopathic hemorrhagic sarcoma (Kaposi sarcoma), sweat gland carcinoma, dermatofibrosarcoma protuberans, angiosarcoma, etc.

Histopathological examination has a definite significance for the diagnosis and classification of skin cancer and is easy to operate. The histopathology of basal cell carcinoma and squamous cell carcinoma is described as follows:

1) Basal cell carcinoma: There are clearly demarcated tumor cell groups in the dermis. The nuclei are slightly larger than normal and are oval or elongated. There is little cytoplasm. The boundaries between cells are unclear and there are no spaces between cells.

Therefore, it seems like many cell nuclei are densely distributed in a common serous fluid, and there is no significant difference in nuclear staining. Sometimes cells with multiple nuclei or darkly stained nuclei or irregular stellate nuclei can be seen. Connective tissue proliferates around the tumor cell groups, and the outermost layer is arranged in a grid-like manner as plug-shaped cells. Many immature fibroblasts and mature fibroblasts can often be seen mixed around the tumor tissue. The stroma of basal cell carcinoma contains mucin, and when the sections are made, the stroma shrinks, causing the stroma to separate from the edge of the tumor mass in a fissure-like manner, which is of certain significance for the diagnosis of this disease. In histopathology, basal cell carcinoma can be divided into two major categories: differentiated and undifferentiated. The undifferentiated type can manifest as a solid type, a pigmented type, a fibrotic type, or a hard plaque-like, superficial type. The solid type can be seen as cancer masses of varying amounts and shapes buried in the dermis; there is more melanin between the pigmented tumor cells; the fibrotic or hard plaque-like type has significant connective tissue hyperplasia, and the connective tissue is striped.

2) Squamous cell carcinoma: Cancer cells invade the dermis in clusters or cords, with varying numbers of normal and atypical incompletely differentiated squamous cells and dyskeratinized cells. The more atypical squamous cells there are, the higher the malignancy, which is manifested by unequal cell sizes, atypical nuclear divisions, dark staining, basophilic cytoplasm, and no intercellular bridges. The more differentiated the squamous cells are, the more keratinized they are as they approach the center, and the center can be completely keratinized. Squamous cell carcinoma can be divided into four degrees according to the proportion of atypical squamous cells in the tumor.