How harmful is gallbladder cancer?

Among the malignant tumors of the gallbladder, gallbladder cancer ranks first, and others include sarcoma, carcinoid, primary malignant melanoma, giant cell adenocarcinoma, etc. Primary gallbladder cancer is relatively rare in clinical practice and has not attracted people's attention for a long time. According to domestic textbooks, it only accounts for about 1% of all cancers. So how harmful is gallbladder cancer?

1. Jaundice, manifested by yellowing of the mucous membranes and skin. Severe jaundice is mostly obstructive. Once jaundice occurs, the disease is usually in the late stage.
2. Mass in the right upper abdomen. A relatively smooth and enlarged gallbladder can be felt in the right upper abdomen. When there is no adhesion to the surrounding tissue, it is highly mobile. When there is adhesion to the surrounding tissue, several masses can be felt. Sometimes, an enlarged liver or a mass of duodenal obstruction can be felt. Abdominal masses. In nearly half of the cases, a mass can be felt in the gallbladder area in the right upper abdomen at the time of initial diagnosis. Some parts are hard and have a nodular feel. This mass is the gallbladder. Occasionally, due to obstruction of the cystic duct, the gallbladder may accumulate water or form an abscess, causing tenderness in the gallbladder area and rebound pain. Its signs are very similar to those of acute cholecystitis or obstructive cholangitis.
3. Weight loss. Most cases show gradual weight loss, fatigue, and cachexia.
4. Physical signs caused by metastasis: in some cases, metastatic lymph nodes can be felt above the clavicle, and metastatic masses may also appear in the breast, etc. In advanced cases, there may be gastrointestinal bleeding, ascites, and liver failure due to portal vein compression.