What is the pathological examination method for secondary liver cancer

Secondary liver cancer is also called metastatic liver cancer. Malignant tumors in various parts of the human body can be transferred to the liver through the blood or lymphatic system. Tumors in adjacent organs can directly infiltrate the liver and form secondary liver cancer. In this case, the liver is often an innocent victim. It has nothing wrong with itself, but is affected by other tumors. The livers of patients with primary liver cancer mostly have a basis of hepatitis or cirrhosis. Liver cancer is just the result of long-term liver disease. What is the pathological examination method for secondary liver cancer?

When a malignant tumor grows to a diameter greater than 2 cm, it can release a large number of cancer cells into the blood circulation every day. These cancer cells can eventually reach the liver by "going with the flow". The structure of the liver is like a thick sponge soaked in blood. The blood perfusion volume is large but the flow rate is slow. Tumor cells can easily enter the liver substance and stay there. Among them, the more malignant tumor cells that reach the liver can secrete certain growth factors to promote the proliferation of their own tumor cells and stimulate the growth of new capillaries around them, thus gradually forming independent tumor cell clusters. It will not take long for tumor metastasis lesions of a size visible to the naked eye to form.

a. The surgeon should mark the type and quantity of specimens to be sent for examination on the pathology application form. The surgical margins, suspicious lesions, and the margins of important blood vessels and bile ducts can be stained with dyes or marked with sutures. Small tissue specimens and lymph nodes should be placed in separate containers and labeled; b. In order to maximize the integrity of intracellular nucleic acids and proteins and prevent cell autolysis, tumor specimens should be delivered to the pathology department within 30 minutes of ex vivo ex vivo for incision and fixation; c. After the case can accept the specimen, fresh tissue should be cut and frozen in the tissue bank without affecting the pathological diagnosis for molecular pathology examination. A section should be made every 25px along the maximum diameter of the tumor, and the continuity of the specimen should be maintained; d. Fix the specimen at room temperature in 10% neutral buffered formalin solution 4 to 5 times the volume of the specimen for 12-24 hours.