What is the chance of inheriting liver cancer?

As to whether liver cancer is a genetic disease, experts at home and abroad have basically reached a consensus: liver cancer is a multi-gene genetic disease, and its occurrence is the result of the combined effects of genetic and environmental factors. In other words, genetic factors are the basis, which determines the susceptibility of the human body to tumors; environmental factors are the inducement, which contributes to the occurrence of liver cancer.

Studies have found that genetic polymorphisms of some genes related to immunity, inflammation, DNA repair, cell proliferation, apoptosis, carcinogenic compounds, and alcohol metabolism and detoxification are closely related to susceptibility to liver cancer. For example, the liver is an important detoxification organ in the human body. Some people have a strong ability to degrade carcinogens, so less is accumulated in the body, while others have a poor detoxification ability and more is accumulated, which is the polymorphism of the human body's toxic metabolism enzymes. It determines the different susceptibility of individuals to chemical carcinogens and mutagens in the environment, thus leading to different susceptibility to tumors.

People in the same family have similar genetic characteristics and are more likely to have the same liver cancer susceptibility genes.

This results in similar susceptibility to liver cancer among people in the same family, especially direct relatives. Epidemiological surveys have also found that the direct relatives of liver cancer patients have a significantly higher chance of developing liver cancer than the general population.

The vertical and horizontal transmission characteristics of the liver lead to familial clustering of hepatitis B patients.