5 commonly used herbal medicines for malignant bone tumors

Botanical drugs refer to drugs extracted from plants that contain anti-tumor components such as alkaloids. They are cell cycle-specific drugs. Currently, the commonly used drugs for the treatment of malignant bone tumors include paclitaxel, etoposide, teniposide, taxotere, vincristine, etc. Their effects and dosages are mainly as follows:

1. Paclitaxel: Paclitaxel can promote the assembly of microtubule dimers into microtubules and then stabilize the microtubules by preventing the depolymerization process. This reorganization is necessary for the cell life cycle and division function.

Dosage and administration: 135-200 mg/m2 intravenous drip for 3 hours, repeated every 3 weeks.

2. Etoposide: Etoposide exerts its cytotoxic effect by acting on DNA topoisomerase II, preventing DNA from reconnecting after breakage.

Dosage and administration: 60-100mg/m2, for 3-5 consecutive days.

3. Teniposide: Teniposide can inhibit thymidine synthesis on the one hand, and act on DNA topoisomerase II on the other hand, thereby inhibiting DNA synthesis and mitosis.

Dosage and administration: 100mg/m2, for 3 consecutive days.

4. Taxotere: Taxotere can promote the assembly of microtubule dimers into microtubules and then stabilize the microtubules by preventing the depolymerization process, but the effect is slightly stronger than that of Taxotere.

Dosage and administration: 75 mg/m2, intravenous drip for 1 hour, repeated every 3 weeks.

5. Vincristine: Vincristine works by inhibiting the polymerization of microtubules. It can also synchronize cell proliferation. Other chemotherapy drugs used a few hours later can improve the efficacy.

Dosage and administration: 0.03 mg/kg/time, intravenous administration.