Five major factors that induce colorectal cancer

Although the exact cause of colorectal cancer is still unclear, clinical findings show that the incidence of colorectal cancer increases with age. About 1/4 of colorectal cancer patients have a family history, and people with a history of inflammatory bowel disease have a 30-fold higher risk of developing the disease than normal people. In addition, mutations in the corresponding genes are also a predisposing factor for colorectal cancer.

1. As age increases, the incidence rate increases

As age increases, the duration of various pathogenic factors irritating the colon mucosa also increases. Most patients develop the disease after the age of 50.

2. About 1/4 of colorectal cancer patients have a family history

If a person's first-degree family member, such as a parent, has had colorectal cancer, his risk of developing the disease in his lifetime is 8 times higher than that of the general population? About 1/4 of new patients have a family history of colorectal cancer?

3. People with a history of inflammatory colitis are at higher risk

Certain colon diseases such as Crohn's disease or ulcerative colitis may increase the risk of colorectal cancer. Their risk of colon cancer is 30 times that of the general population.

4. Precancerous lesions such as colorectal polyps are prone to malignant transformation

Most colorectal cancers develop from small precancerous lesions. The main precancerous lesions are intestinal polyps. Among them, villous adenomatous polyps are more likely to develop into cancer, with a chance of malignant transformation of about 25%; tubular adenomatous polyps have a malignant transformation rate of 1-5%.

5. Mutations in the corresponding genes can lead to the occurrence of colorectal cancer

Familial adenomatous polyposis and hereditary non-polyposis colorectal cancer are both caused by mutations in the corresponding genes. Patients with these diseases not only have a significantly increased risk of developing the disease, but also develop the disease at a younger age.