What is the connection between midkine and pancreatic cancer

There are many factors that affect pancreatic cancer, some of which are not well known to people. However, from a medical point of view, the impact of midkine on pancreatic cancer cannot be ignored. The expression level of midkine directly affects the severity of pancreatic cancer tumors.

Medical researchers used immunohistochemistry to detect the protein expression of midkine and microvascular density (MVD) in 52 pancreatic cancer tissues, and compared them with clinical pathology and prognostic indicators. Results: The average MVD of pancreatic cancer was 64±18MK, and the positive expression rate was 73%. The positive expression rate of midkine in patients with lymph node metastasis, stage III-IV and high MVD was significantly higher than that in patients without lymph node metastasis, stage I-II and low MVD. The postoperative survival time of patients with high midkine expression was significantly shorter than that of patients with low midkine expression.

Through the analysis of the research results and the impact on pancreatic cancer, it was found that the positive rate of midkine in patients with pancreatic cancer in stages III and IV and with lymph node metastasis was significantly higher than that in patients with pancreatic cancer in stages I and II and without lymph node metastasis, indicating that midkine directly affects the degree of pancreatic cancer. The MVD in pancreatic cancer tissue was significantly higher than that in adjacent pancreatic tissue and normal pancreatic tissue, indicating that angiogenesis increased significantly in pancreatic cancer. The MVD of patients with positive expression of midkine protein was significantly higher than that of patients with negative expression of midkine protein, indicating that midkine protein expression in pancreatic cancer is closely related to angiogenesis. The median survival time after surgery of patients with positive expression of midkine protein was significantly shorter than that of patients with negative expression of midkine protein, indicating that the relationship between midkine and pancreatic cancer is directly related to the prognostic evaluation of pancreatic cancer.

The above is the experimental research conducted by medical experts on the effect of midkine on pancreatic cancer. We hope that readers can realize more factors affecting pancreatic cancer by understanding the research methods and conclusions, pay attention to their own physical condition from multiple aspects, and effectively understand the disease condition.

For more information, please visit the pancreatic cancer disease special topic at http://www..com.cn/zhongliu/yxa/ or consult an expert for free. The expert will then give a detailed answer based on the patient's specific situation.