Purpura urine protein a plus sign

Problems in the body can be seen through urine, among which the symptoms of purpura and proteinuria should be taken seriously. Some people find a plus sign of purpura urine protein when checking their urine, and they don’t know what kind of disease it will cause. It is understood that if this problem occurs, you should pay attention to the health of your kidneys, as uremia may have already developed. The most direct way to discover this disease is the presence of protein in the urine, which must be taken seriously.

If patients with Henoch-Schonlein purpura have fluctuations in urine test results, and have proteinuria and hematuria, they need to pay close attention, as this may mean that the disease has affected the kidneys. Professor Hu Guisheng said that general microscopic hematuria will not cause significant kidney damage and systemic effects on children with Henoch-Schonlein purpura, but long-term proteinuria will lead to kidney damage. There are two aspects, one is the systemic impact, and the other is renal toxicity.

1. Hypoproteinemia

If a large amount of proteinuria is excreted, hypoproteinemia will occur in the blood, which can cause edema. The body's resistance will also decrease, and many important functions will also be affected. Professor Hu Guisheng said that this situation often occurs in the acute phase of purpura nephritis, and the amount of proteinuria in the recovery phase is generally not large.

2. Uremia

Impact on glomeruli: There are proteins in the urine, which will stimulate the mesangial cells in the glomeruli, causing mesangial cell damage, proliferation and increased synthesis of mesangial matrix. This is one of the basic mechanisms leading to glomerular sclerosis. If the glomeruli are sclerotic, renal function will be reduced, and uremia will be more likely to occur.

3. Renal failure

Effects on renal tubules. When proteinuria occurs, the amount of protein entering the renal tubular epithelial cells increases, which can damage the renal tubular cells and stimulate cell proliferation. The most serious consequence is the occurrence of renal tubular fibrosis, which can also damage renal function and lead to renal failure. Professor Hu Guisheng reminds: If patients with Henoch-Schönlein purpura have long-term proteinuria, it is a very serious problem. It is necessary to inform the doctor promptly and seek medical attention. The doctor will actively deal with the situation, reduce and eliminate proteinuria in time, prevent the child from experiencing renal impairment, and strive for a good prognosis as much as possible.