Conditions for bone marrow transplant donors

There are many people suffering from blood diseases in today's society. Therefore, we should pay attention to preventing the occurrence of blood diseases. Everyone should be aware of the bone marrow, which is a very important part of the body. When a person develops leukemia, a bone marrow transplant is needed, but it is necessary to find people with matching bone marrow. Bone marrow donors need to meet certain conditions, so what are the conditions for bone marrow transplant donors?

1. Bone marrow transplant donor conditions

The suitable age for bone marrow donation is 18-45 years old. The health requirements are the same as those for blood donation, that is, the health of the donor cannot be affected by donating bone marrow, and the patient cannot have new adverse factors due to receiving bone marrow. What is important is that the donor must not have infectious diseases that can be transmitted through blood, such as hepatitis B, hepatitis C, AIDS, etc.

2. Does bone marrow transplantation have any impact on the donor?

In fact, bone marrow transplantation will not have much impact on the donor. As long as not all of the bone marrow is transplanted, but only a part of it, there will be no impact. Because current bone marrow transplantation mostly uses the method of in vitro separation of stem cells, which is to draw arterial blood from the elbow and use a blood cell separator to separate a large number of hematopoietic stem cells from the blood. As long as the donor adjusts his or her body to the best condition when donating, hematopoietic stem cells are a type of cell with strong regenerative ability. Generally, the hematopoietic stem cells of a healthy donor can replenish the donated stem cells about ten days after donation, so there is no need to worry about any impact on the body.

3. Bone marrow transplant success rate

Previously, the news media reported that the actual success rate of bone marrow transplantation was around 50%, but the medical community recognized it to be around 33%. That is, 1/3, 1/3, 1/3 point of view: 1/3 of patients fail in transplantation; 1/3 relapse within half a year after transplantation; 1/3 of patients achieve successful transplantation.

What are the risks of bone marrow transplantation?

1. Early complications:

1.1. Acute toxic side effects related to pretreatment such as oral ulcers, acute gastrointestinal reactions, etc.;

1.2. Hemorrhagic cystitis;

1.3. Hepatic veno-occlusive disease;

1.4. Capillary leak syndrome;

1.5. Implantation syndrome;

1.6. Diffuse alveolar hemorrhage syndrome;

1.7. Thrombotic microangiopathy;

1.8. Idiopathic pneumonia syndrome;

1.9, infection;

1.10. Graft-versus-host disease.

2. Late complications:

2.1. Depigmentation and pigmentation of skin and mucous membranes;

2.2. Decreased glandular secretion function;

2.3. Cataract;

2.4. Leukoencephalopathy;

2.5. Growth and development disorders and endocrine disorders;

2.6. Secondary malignant tumors.