Is positive anti-sperm antibodies serious?

Anti-sperm antibodies, an immune cell, are the most troublesome for couples who are preparing to conceive, because this antibody will prevent the woman from becoming pregnant. After the sperm enters the vagina, it is directly digested or eliminated from the body. Therefore, for couples who are preparing to conceive, if the anti-sperm antibody test is positive, you should first control the number of anti-sperm antibodies in order to increase the chance of conception. Now let’s take a look at how serious the consequences of this symptom are.

The English abbreviation of anti-sperm antibody is called AsAb. If the sperm and egg of the couple preparing for pregnancy are likened to a pair of lovers who are in love with each other, then the anti-sperm antibody is the big villain that prevents them from being together and destroys their union, like the evil mother-in-law who breaks up the couple... In short, with it, the sperm and egg cannot be together well. Therefore, it is the legendary "killer" of good pregnancy and the notorious infertility factor.

How are anti-sperm antibodies produced?

Let’s first look at female anti-sperm antibodies. If a woman has anti-sperm antibodies in her body, they will react with the antigen system in her body and kill the sperm, causing the sperm to "die before it even starts its mission". The sperm will not be able to successfully reach the ampulla of the fallopian tube to meet and combine with the egg, eventually causing infertility.

Why do women produce anti-sperm antibodies? When a couple has frequent sexual intercourse, the woman's vagina will be exposed to a large amount of male sperm, which will produce antigens and thus anti-sperm antibodies. If a woman suffers from inflammation such as salpingitis, vaginitis, endometritis, etc., when sperm enters the vagina, some of the sperm's infection will be exposed to the woman's immune system, producing cross-antigens and leading to the appearance of anti-sperm antibody lesions. Therefore, the female anti-sperm antibody test will be positive.

Men also have anti-sperm antibodies in their bodies. For example, they may be affected by genetic factors. Certain genetic factors lead to the existence of anti-sperm antibodies, causing immune reactions and chromosomal abnormalities, thereby rejecting the formation of sperm, which can directly cause the occurrence of anti-sperm antibodies. If a man suffers from diseases such as prostatitis, he will also develop anti-sperm antibodies, which will prevent sperm from forming.

Therefore, even if you use condoms for contraception, it is possible that anti-sperm antibodies will be positive due to genetic factors.

It can be seen that men's anti-sperm antibodies will cause men to be unable to produce sperm smoothly, while women's anti-sperm antibodies inhibit the combination of sperm and egg. Although there are slight differences, the final result is the same, that is, sperm and egg cannot combine and conception cannot be successfully achieved.