Clear cell sarcoma of soft tissue?

Soft tissue clear cell sarcoma is generally a malignant tumor that often occurs in the tendon and tendon sheath of the human body. The population with a higher incidence rate is adolescents or young adults. Most patients usually involve the limbs when the disease occurs. This type of tumor generally grows relatively slowly, but because it is a malignant tumor, it must be treated in a timely manner.

Clear cell chondrosarcoma is similar to chondroblastoma and is a rare subtype with a malignancy between grade I and II central chondrosarcomas. This disease often occurs in the epiphysis or bone protrusions of the proximal femur, proximal humerus, flat bones and short bones. The age and gender of onset are similar to those of chondrosarcoma. Clinically, joint pain, effusion and limited movement are common manifestations. This disease is mainly treated with surgery, is prone to recurrence, and rarely metastasizes.

Clear cell sarcoma, also known as soft tissue malignant melanoma, is a rare soft tissue malignant tumor, accounting for about 1% of soft tissue sarcomas. This disease can be found in any age group, with the peak age of onset being 20 to 40 years old, and is slightly more common in women than in men. The tumor grows slowly and is prone to occur in the limbs, with the vast majority occurring in the lower limbs, especially the ankles and knees.

Currently, surgical resection is still the main treatment, but the anatomical location often does not allow extensive surgical resection. If the lesion is too large or the location is not suitable for extensive resection, selective amputation is often performed. Incomplete local excision leading to recurrence is the main reason for treatment failure. Recurrence or metastasis is common, with more than half of patients eventually developing metastasis, most often to lymph nodes, lungs, and bones. However, the clinical efficacy of postoperative radiotherapy and chemotherapy is poor.

However, amputation is cruel to young patients and seriously affects their quality of life. For residual or recurrent tumors after surgery, local freezing or radioactive particle placement can be used to improve the local control rate of the tumor. Combination biological therapy is expected to inhibit distant metastasis and thus improve patient survival.

The clinical manifestations of soft tissue clear cell sarcoma are as follows:

1. Tumors generally appear as slowly growing masses, with the course of the disease lasting from several weeks to several years. Pain and/or tenderness are present in 50% of cases. MRI examination of clear cell sarcoma generally shows a benign tumor, and in about half of the T1 cases, the tumor density is slightly higher than the muscle shadow.

2. Typical clear cell sarcoma has consistent structure, nested or bundled. The tumor cells are polygonal or spindle-shaped with abundant eosinophilic or clear cytoplasm. Fibrous septa delineate nests of tumor cells.

3. About 50% of tumors have scattered rosette-like multinucleated giant cells, and the cell division activity and pleomorphism are generally relatively low. Melanin is rarely detected by guanidine staining, but can be detected in about 50% of cases.

4. Rare morphological variations of typical lesions include spindle cell arrangement, pleomorphism and marked mitotic activity (especially in recurrent and metastatic lesions), solid round cells, microcyst formation, and myxoid stroma.

From this we can see that we know that soft tissue clear cell sarcoma occurs in the limbs and has its own symptoms, so patients must receive timely treatment.