Is glioblastoma hereditary?

People's body structure is relatively complex. It is always easy to breed some diseases, which are relatively rare in daily life. For example, glioblastoma is a relatively minor phenomenon that occurs in daily life. However, glioblastoma is very serious and sometimes causes symptoms such as epilepsy, nausea, vomiting, and headache. When something goes seriously wrong, many people, especially those like you these days, worry that the disease will be passed on to the next generation. So for a disease like glioblastoma that is very harmful to the body, is it hereditary?

What are the common manifestations of glioblastoma?

Glioblastoma, like other brain cancers, can cause seizures, nausea, vomiting, headaches, muscle weakness, visual changes, and hemiparesis. The most important symptoms are worsening problems with memory, personality, or thinking. These symptoms are primarily due to damage to the temporal and frontal lobes.

The specific symptoms depend on where the tumor appears. Generally, these symptoms will appear quickly, but occasionally the tumor may not cause symptoms until it reaches a considerable size.

Where do glioblastomas usually occur?

Glioblastoma can grow in any part of the cerebral hemisphere, growing in an infiltrative manner, often invading several lobes and deep structures, and can also spread to the contralateral cerebral hemisphere through the corpus callosum. However, glioblastoma rarely metastasizes to distant sites outside the central nervous system.

What are the complications of glioblastoma?

Because brain tumors grow rapidly and compress brain tissue, symptoms of increased intracranial pressure are obvious, and almost all patients have symptoms of headache and vomiting. There are also mental changes, limb weakness, impaired consciousness, speech disorders, varying degrees of hemiplegia and even epileptic seizures.

What are the consequences of glioblastoma?

Glioblastoma is highly malignant and if not treated promptly, the disease will quickly progress to the advanced stage. The patient's symptoms will also progressively worsen. Even if further treatment is given, it will delay the disease, make treatment more difficult, and increase the patient's mortality rate.

Causes

What are the common causes of glioblastoma?

The cause is currently unknown, and most glioblastomas occur sporadically.

Glioblastoma may be slightly related to ionizing radiation, may be related to polyvinyl chloride, which is commonly used in construction, and may be related to malaria.

Other risk factors include being more likely to be in men than in women, being over 50, having a mild astrocytoma, and having neurofibromatosis, tuberous sclerosis, Hippel-Lindau disease, Li-Fraumeni syndrome, or Teucher's disease.

Is glioblastoma hereditary?

Glioblastoma has not yet been shown to be hereditary.

What are the treatments for glioblastoma?

The best treatment is combined therapy, which is postoperative adjuvant radiotherapy combined with adjuvant chemotherapy after initial surgical treatment. Treatment of glioblastoma usually includes the following:

Surgery: Doctors try to remove as much tumor tissue as possible during surgery, which helps relieve symptoms and prolong life. However, surgery may also damage healthy brain tissue. During surgery, doctors remove as much diseased tissue as possible without damaging healthy areas.

Radiation therapy: Radiation therapy can kill some cancer cells. Most people with glioblastoma receive radiation therapy after surgery.

Chemotherapy: Treatment with drugs that kill cancer cells or stop them from growing. The main drugs currently recommended are temozolomide and bevacizumab.

Electric fields: Use alternating electric fields to hinder the division of malignant cells. The device is connected directly to the shaved scalp and generates a low-intensity electric field that surrounds the tumor.

Immunotherapy: There are small trials that have shown immunotherapy to be effective, but larger trials are testing it.