Will autoimmune liver disease be passed on to the next generation?

Autoimmune liver disease is also called autoimmune liver disease. This disease will directly cause the body's immune function to be invaded by bacteria and continue to decline. It may even cause many complications, and there will be some other disease factors in the body. It is unknown whether this disease is inherited or contagious, because each person's disease is different.

Autoimmune liver diseases (AILD) refer to a group of liver diseases in which the direct cause of liver damage is autoimmune reaction rather than viral infection. It mainly includes three types: autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. The incidence of autoimmune liver disease tends to increase year by year. Patients with autoimmune liver disease often have other autoimmune diseases, and some patients with viral hepatitis also have autoimmune liver disease.

Clinical laboratory diagnosis of AILD

Clinical laboratory diagnosis of AILD should include immunoglobulin measurement, liver function test, autoantibody measurement and liver biopsy. These patients have significantly elevated serum immunoglobulins and abnormal liver function. Patients with primary biliary cirrhosis and primary sclerosing cholangitis often have elevated bilirubin and bile acid levels.

1. Key points of laboratory diagnosis of autoimmune hepatitis: the presence of blood biochemical tests and pathological evidence of hepatitis; the increase of serum alkaline phosphatase is not as obvious as that of serum transaminase; the presence of related autoantibodies and hypergammaglobulinemia (mainly manifested as increased IgG in serum in the initial stage), and increased erythrocyte sedimentation rate; the serological indicators of general hepatitis virus infection are negative, but attention should be paid to the overlap with viral hepatitis; the patient has a genetic tendency and can express HLA-B8, DR3 or DR4 antigens; the symptoms are alleviated after immunosuppressive treatment, and drug-induced liver disease, alcoholic liver disease, metabolic liver disease, as well as PBC and PSC should be excluded, but attention should be paid to their overlapping syndromes. Autoantibodies are of great significance in the diagnosis of AIH.

2. Key points of laboratory diagnosis of primary biliary cirrhosis: The presence of multinuclear dot-type antinuclear antibodies SP100, gp210, LKM-1 antibodies and AMA antibodies. AMA antibodies are its most important feature, and high-titer AMA-M2 autoantibodies usually have important diagnostic value; hypergammaglobulinemia is also present; in addition, increased concentrations of serum cholesterol and lipoprotein, serum haptoglobin and serum bilirubin, and increased angiotensin-converting enzyme activity are all unique manifestations of the disease.

3. Key points of laboratory diagnosis of primary sclerosing cholangitis: Hypergammaglobulinemia. Adult patients mainly have IgM, but children patients mostly have elevated IgG. Characterized by the presence of resistance to soluble liver antigen SLA. Patients' CIC, C3, C4, liver enzyme spectrum and bilirubin are generally increased. The diagnosis of this disease requires exclusion of other biliary diseases (such as gallstones).