The effect of sodium ferulate injection

People with cerebrovascular diseases should pay special attention to diet, exercise, etc. in their daily lives, and keep a good attitude, not be anxious when encountering things, and not do too much work or exercise excessively. This disease is very dangerous. For people with cerebrovascular diseases, sodium ferulate is a familiar and commonly used drug ingredient, but there are many contraindications when using this drug that should be fully understood.

1. Ingredients

The main ingredient of this product is sodium ferulate, and its chemical name is 3-methoxy-4-hydroxycinnamic acid sodium salt dihydrate.

2. Properties

This product is a colorless or slightly yellow clear liquid.

3. Indications

It is used for cerebrovascular disease, atherosclerosis, coronary heart disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis and other vascular diseases, as well as leukocytopenia and thrombocytopenia. It can also be used for migraine and vascular headache.

4. Specifications

100ml: 0.1g sodium ferulate and 0.9g sodium chloride

5. Usage and Dosage

Intravenous drip, 100mg~300mg each time, once a day, slow drip.

Adverse Reactions

Occasionally there is a transient rash reaction, which disappears after stopping the drug.

6. Taboo

It is contraindicated for those who are allergic to this product.

Pregnant and lactating women

Pregnant women should not use it, and breastfeeding women should use it with caution.

Drug interactions

Not yet clear.

Pharmacology and Toxicology

7. Pharmacology

It is a non-peptide endothelin receptor antagonist that can antagonize endothelin-induced vasoconstriction, blood pressure increase and vascular smooth muscle cell proliferation, reduce vascular endothelial damage; increase NO synthesis, relax vascular smooth muscle; inhibit platelet aggregation, anti-coagulation, and improve blood rheology characteristics. This product can also inhibit the synthesis of cholesterol, lower blood lipids, scavenge free radicals, prevent and treat lipid peroxidation damage; affect complement, enhance immune function, and have certain analgesic and antispasmodic effects.

8. Toxicology

After intravenous administration, the median lethal dose (LD50) for mice is 1.7 g/kg.

Pharmacokinetics

After intravenous administration, the plasma protein binding rate is 20.6%, the distribution half-life (t1/2α) in rats is 3 minutes, and the elimination half-life (t1/2β) is 11.46min±3.2min. It is rapidly distributed, can pass the blood-cerebrospinal fluid barrier, is mainly excreted through the kidneys, and is not easily accumulated in the body.