Low cardiac troponin

Many people don’t know what cardiac troponin is. Cardiac troponin is actually a regulatory protein for the contraction of myocardial muscles in our human body. It plays an important role inside the human body. But sometimes cardiac troponin will change, either low or high. So what should we do if cardiac troponin is low? Today I will tell you what to do if your cardiac troponin is low.

cTn is composed of three different gene subunits: cardiac troponin T (cTnT), cardiac troponin I (cTn I) and troponin C (TnC).

Troponin T (TnT) has a molecular weight of 37KD and is the binding subunit of tropomyosin. There are three isoforms: skeletal muscle troponin T (sTnT) includes fast skeletal muscle type and slow skeletal muscle type, in addition to cardiac muscle type. Most of cardiac troponin T (cTnT) exists in the form of CTI complexes on the filaments, and 6%-8% exists in the free form in the myocardial cytoplasm. Because the genes encoding cTnT and skeletal muscle TnT are different, cTnT is not expressed in skeletal muscle. cTnT was 40% heterologous to the two skeletal muscle isoforms. The cTnT molecule is stable, hydrophilic, and has good reactivity with specific antigenic determinants. The monoclonal antibodies currently used are capture antibodies and labeling antibodies specific to the myocardium.

There are three subtypes of TnI (troponin I): skeletal muscle troponin I (sTnI) includes fast skeletal muscle type and slow skeletal muscle type, which have similar molecular weight (20KD), but there is about 40% difference in amino acid sequence between the two; the third is the cardiac muscle type. There is also a 40% difference in the amino acid sequence between cardiac troponin I (cTnI) and the skeletal muscle type. However, the amino terminal of human eTnI has 31 more amino acids than sTnI, making it molecular

The weight reaches 22KD. This unique sequence gives it high myocardial specificity and helps to prepare the corresponding monoclonal clone. cTn exists in myocardial cells in the form of cTnI-CT complex and free cTnI. After being released into the blood circulation when the myocardium is damaged, cTnI-CT can be further decomposed into cTnI-C complex and free cTnI. Therefore, in addition to cTnI CT and free cTnI, there is also cTnI-C in the blood circulation, and cTnI-C is its main form in the blood. Its metabolites are excreted from the body by the kidneys.

TnC has a molecular weight of 18KD and is a Ca binding subunit, with each molecule binding 2 Ca. The structure of TnC in cardiac and skeletal muscle is the same.