Plasma prothrombin time is high

The term "plasma prothrombin time" is too professional. Many people do not know what it means when they see it. This medical professional term refers to adding special substances to the blood to make the blood coagulate. When the patient takes oral contraceptives, it will affect the result to a certain extent. Therefore, before collecting the sample, the person being collected must be in a quiet state and on an empty stomach.

High plasma prothrombin time

1. The normal value of prothrombin time is 12-14 seconds, and its normal activity is 75% to 100%. Prothrombin time mainly reflects whether exogenous coagulation is normal. Less than 40% can be diagnosed with acute severe hepatitis.

2. Most coagulation factors are synthesized in hepatocytes. When liver function is normal, the content and activity of coagulation factors are within the normal range. When the liver parenchyma is damaged, the content and activity of coagulation factors may be reduced to varying degrees, often causing clinical manifestations such as bruises on the gums, nose, and lips, etc.

3. In acute hepatitis, the decrease in prothrombin activity is not obvious. If the patient is seriously ill with hepatitis B, or has cirrhosis or chronic hepatitis B, when the prothrombin activity is tested, it will be found that the activity of prothrombin is significantly reduced, indicating that the condition has worsened sharply and the liver cells have been severely damaged. The basis for judgment is: the activity of prothrombin is less than 40%, which is the definite limit of hepatocellular necrosis. In addition, it is also the main indicator for judging severe hepatitis and cirrhosis.

Prothrombin time (PT): 11-13s International normalized ratio (INR): 0.82-1.15

1. Prolonged PT:

PT is prolonged when it exceeds the normal control by more than 3 seconds or INR exceeds the upper limit of normal. (1) Deficiency of coagulation factor VII causes obstruction of the extrinsic coagulation pathway. (2) Deficiency of coagulation factors V, X, fibrinogen and prothrombin leads to obstruction of the common coagulation pathway, such as liver disease, obstructive jaundice, malabsorption syndrome and hypo(a)fibrinogenemia. (3) An increase in anticoagulants in the blood affects blood coagulation, such as the presence of coagulation factor antibodies, oral anticoagulants, heparin treatment, and systemic lupus erythematosus. (4) The activity of the fibrinolytic system is enhanced, which relatively weakens the coagulation effect, such as primary hyperfibrinolysis and the hypocoagulable phase of DIC.

2. Shortened PT:

It is mainly seen in prethrombotic states and thrombotic diseases when coagulation function is enhanced, such as the hypercoagulable phase of DIC, myocardial infarction, angina pectoris, cerebrovascular disease, diabetes, pregnancy-induced hypertension, deep vein thrombosis, nephrotic syndrome, etc.

3.PT is used to monitor the dosage of oral anticoagulants:

Clinically, an INR of 2-4 is the appropriate range for oral anticoagulant treatment; if the INR>4.5, it indicates that the medication should be reduced or stopped.