Indications of chloral hydrate solution

Chloral hydrate solution is a common drug for treating insomnia. It has a good sedative and hypnotic effect. If the patient suffers from insomnia, this drug can be used for treatment. It can achieve a good short-term treatment effect, but it cannot be taken for a long time. Generally, the effect will decrease a lot after two weeks of use. In addition, it also has a good anticonvulsant effect and can play a certain role in the treatment of epilepsy patients.

Indications

1. Treat insomnia, suitable for patients who have difficulty falling asleep. As a hypnotic, it is effective in the short term, but ineffective if taken continuously for more than two weeks.

2. Taking the medication before anesthesia, before surgery, and before sleep EEG examination can calm people and relieve anxiety, making the corresponding treatment process safer and smoother.

3. Anticonvulsant, used for the treatment of status epilepticus, and can also be used for convulsions caused by high fever, tetanus and epilepsy in children.

Dosage

Common dosage for adults: For hypnosis, take orally or by enema 0.5~1.0g, once before bedtime. For oral use, it is advisable to prepare it into a 10% solution or jelly. For enema, it is advisable to dilute the 10% solution 1~2 times and inject it.

Sedation: 0.25g at a time, 3 times a day, after meals. For status epilepticus, 20-30 ml of 10% solution is usually used, which should be diluted 1-2 times and then injected all at once to be effective. The maximum limit is 2g at one time.

Common dosage for children: For hypnosis, 50 mg/kg of body weight or 1.5 g/m2 of body surface area at a time, taken before bedtime, with a maximum limit of 1 g at a time; it can also be taken at 16.7 mg/kg of body weight or 500 mg/m2 of body surface area, 3 times a day. For sedation, 8 mg/kg body weight or 250 mg/m2 body surface area at a time, with a maximum limit of 500 mg, 3 times a day, after meals.

Enema, 25 mg/kg body weight each time. The maximum amount is 1g each time.

Adverse Reactions

1. It is irritating to the gastric mucosa and can easily cause nausea and vomiting.

2. Large doses can inhibit myocardial contractility, shorten myocardial refractory period, and inhibit the respiratory and vasomotor centers in the medulla oblongata.

3. It has damaging effects on liver and kidneys.

4. Allergic rash and urticaria may occur occasionally.

5. Long-term use may cause dependence and tolerance. Sudden discontinuation of the drug may cause serious withdrawal syndrome such as nervousness, hallucinations, irritability, abnormal excitement, delirium, tremors, etc.