Rubescens rubescens is a common Chinese medicine. In recent years, through the understanding of Rubescens rubescens, it was found that it is very effective in treating esophageal cancer and has been widely recognized by the domestic Chinese medicine community. It is very effective in inhibiting many types of cancer tumors. It is an anti-cancer Chinese herbal medicine and is often used in some anti-tumor treatments of the digestive tract, where it has a very good therapeutic effect. (1) Good effect in inhibiting the cause of disease The decoction, alcohol preparation and the contained Rubescens A and B of this product have inhibitory effects on various tumors such as Ehrlich ascites carcinoma and sarcoma 180 in animal experiments. The Rubescens preparation has obvious cytotoxic effects on HeLa cells and esophageal cancer cell CaEs-17. Oridonin has an inhibitory effect on the synthesis of deoxyribonucleic acid and protein in tumor cells. (2) Rubescens rubescens has a significant inhibitory or killing effect on a variety of tumor cells. (3) Anti-tumor mechanism: There are different opinions on the anti-tumor mechanism of Rubescensine A, but a more unified view is that this ingredient is a cytotoxin. (4) Anti-tumor structure-activity relationship: Rubescensine A is a diterpenoid compound with a Kaurene-type structure. It was found that it has an anticancer active center similar to that of sarcoma mycin - a-methylenecyclopentanone. The chemical composition of Rubescens rubescens is very complex, containing a series of substances ranging from monoterpenes, sesquiterpenes to diterpenes and triterpenes. Five diterpenoid components, namely, Rubescens A, B, C, D and E series, were isolated from the ether extract of Rubescens leaves. Nine components have been identified from the leaves and essential oil of Rubescens rubescens. |
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