The causes and hazards of high blood uric acid. High blood uric acid is very harmful

The main causes of high blood uric acid levels are excessive uric acid production in the body and decreased uric acid excretion function. If this phenomenon occurs, it will cause great harm to the human body and may cause diseases such as gout and kidney stones, so everyone must pay attention to it.

What causes increased uric acid?

1. Excessive production of uric acid in the body: About one-third of uric acid comes from food (exogenous), and two-thirds is synthesized by the body (endogenous). Excessive production of uric acid can be divided into two categories: primary and secondary. Primary uric acid elevation is caused by excessive uric acid synthesis, or enzyme defects in the body that lead to rapid synthesis of purines that make up uric acid. Secondary uric acid elevation is often seen in blood diseases, tumors, burns, etc., which result in large amounts of nucleic acid decomposition in the body.

2. Decreased uric acid excretion function: One third of the uric acid in the body is excreted through the bile duct and intestines, and two thirds is excreted through the kidneys. Excretion disorders are divided into three types: primary, secondary, and mixed. Primary disorders are mostly idiopathic or hereditary; secondary disorders are more common in renal dysfunction, dehydration, hyperthyroidism, acidosis, etc.; mixed disorders are more common in alcoholism, obesity, high purine, high-calorie diet, after strenuous exercise, etc.

What are the hazards of hyperuricemia to the human body?

1. When the concentration of uric acid in human blood is too high, needle-shaped crystals will form in soft tissues such as the joint membrane or tendons, causing the body's immune system to overreact, thereby causing an inflammatory response and then gout.

2. Uric acid crystals in the kidneys, ureters, and bladder can easily form stones. For example, excess uric acid in the body forms urate crystals in the renal pelvis, ureters, or in the renal tubules and renal interstitium, forming kidney stones.

3. In addition to stones, hyperuricemia also leads to acute and chronic uric acid nephropathy. Studies have shown that hyperuricemia itself is an important risk factor that aggravates the progressive development of various primary and secondary kidney diseases. Hyperuricemia is also associated with the occurrence of renal hypertrophy, renal function damage, glomerular sclerosis and interstitial fibrosis.

4. Increased blood uric acid is also closely related to the occurrence of cardiovascular diseases. Studies have reported that for every 1 mg/dL increase in blood uric acid (i.e. 60 umol/L), the risk of coronary heart disease increases by 48%. A blood uric acid level >6 mg/dL is an independent risk factor for coronary heart disease, and a blood uric acid level >7 mg/dL is an independent risk factor for stroke.

5. Hyperuricemia often occurs with hypertension, hyperlipidemia, obesity and other diseases, and is also a risk factor for these diseases.