What does it mean when big triple positive turns into small triple positive

In life, many people cannot distinguish between big triple positive and small triple positive, and there is a misunderstanding. Some people think that the infectiousness and severity of big triple positive are more serious than small triple positive, but it is not true. When some patients with big triple positive develop small triple positive, there are two situations. You may want to take a look.

For patients with big triple positive and small triple positive, whether treatment is needed depends on the changes in the patient's liver function, that is, the changes in transaminase, and the degree of viral replication, that is, the amount of HBVDNA.

If the patient has inflammation in the liver, which manifests as increased liver function, antiviral treatment is generally required. If the liver function is normal or slightly higher, the patient may not need treatment for the time being.

Whether it is big triple positive or small triple positive, as long as the DNA is replicated, it is contagious. Of course, its manifestations may be different. People with big triple positive often have higher transaminase and HBVDNA. People with small triple positive may have lower ALT levels and HBVDNA than big triple positive, but both are contagious.

And we need to analyze the specific situation specifically. All the small triple positives are transformed from big triple positives, which can be divided into three situations. The first situation is that after the patient is infected with hepatitis B virus, the body develops a certain resistance and eliminates the virus, so it can be transformed from big triple positive to small triple positive, but this situation is relatively rare. In medicine, we call it natural transfer. Of course, this situation is good, because the virus is basically controlled and the ALT level is basically normal. A small number of people are like this, and more people will not turn negative naturally.

The second situation is that the hepatitis B virus has a strong replication ability. According to medical statistics, the amount of virus produced by the hepatitis B virus every day is 10 to the 12th power, which is 100 billion copies. This is very serious. During such a severe replication process, the hepatitis B virus is prone to mutation. Some of the conversions from big triple positive to small triple positive are due to the mutation of the hepatitis B virus. The mutation occurs in the pre-C region or C region of the hepatitis B virus. After the virus mutates, the e antigen cannot be expressed, and only the e antibody is expressed.