Granuloma annulare

With the continuous improvement of modernization, people's quality of life is also constantly improving, and people's living standards are also constantly improving, and people's pace of life is also constantly accelerating. People do more things, and people know more things, and this annular granuloma is one of them.

As for this type of granuloma annulare, there are actually many different ways to deal with it in society, so people don't need to worry too much about it. Below is some information about this type of granuloma annulare.

This disease is a skin disease characterized by annular raised lesions formed by the fusion of papules and nodules. It most often affects the hands or feet of children and young adults with type 1 diabetes, but it can spread to the arms, neck, and trunk. The cause of granuloma annulare is unknown.

Granuloma annulare first appears as a brightly colored red or reddish-brown mass. These bumps gradually grow together to form ring-shaped plaques. You might mistake it for ringworm. These lumps have a flat middle part of the skin and may be red or shiny. Usually appears on the hands and feet. If it spreads to the trunk, it is called systemic granuloma annulare. Aside from the appearance of the plaques, there are no other symptoms. Granuloma annulare usually resolves on its own. During this time, treatment may be with steroid injections, steroid ointments, or nicotinamide.

Pathological editor: The cause is unknown, and it may be related to trauma, insect bites, sunlight exposure, compression, drugs, viral infection, etc. Some people have detected anti-thyroid antibodies in the blood of patients with disseminated granuloma annulare, and some have used immunological methods such as direct immunofluorescence and macrophage inhibition tests to conduct research, suggesting that delayed hypersensitivity plays an important role in the pathogenesis, but the nature of the antigen is still unclear; some people have used fluorescent antibodies to detect IgM and C3 deposition in the blood vessel walls and the junction of the epidermis and dermis, indicating that this disease is related to vasculitis. The relationship between granuloma annulare and diabetes has been extensively studied. It has been reported that 21% of patients with disseminated granuloma annulare and 10% of patients with localized granuloma annulare have diabetes. Some patients with insulin-dependent diabetes and localized granuloma annulare have increased HLA-B8 detection rates, and some patients with granuloma annulare have increased HLA-A31 and B35.

Many people with mild granuloma annulare do not have obvious symptoms and the disease disappears spontaneously, so no treatment is needed. There are a variety of treatment options, such as topical medications, laser, freezing, surgical excision, local injection of 1% procaine or glucocorticoids (triamcinolone injection) or scratch therapy on the lesions with an injection needle; for disseminated granuloma annulare, oral chloroquine, vitamin E, chlorambucil, and theobromine can be used. In addition, cyclosporine, potassium iodide, dapsone and high-dose niacinamide can be used for treatment. Retinoic acid (isotretinoin or acitretin) is also effective in some patients; oral glucocorticoids have a certain effect (since patients with granuloma annulare may develop diabetes, the systemic use of glucocorticoids may complicate the treatment of diabetes).

Through the above understanding and introduction, I believe everyone can have a certain understanding of this annular granuloma. At the same time, I also hope that everyone can be helped by the above knowledge. At the same time, I also hope that everyone can do more exercises that are more suitable for themselves in daily life, which is also a good thing.