Henoch-Schonlein purpura nephritis

Physical ill-health is often caused by illness. For modern people, Henoch-Schonlein purpura nephritis is a common disease. Therefore, modern people need to pay special attention to the relevant common sense about Henoch-Schonlein purpura nephritis, and then better prevent the occurrence of the disease, so as to stay away from the troubles of the disease and prevent the body from being affected.

Of course, for Henoch-Schonlein purpura nephritis, the causes of the disease are varied, but they seriously endanger the health of the body. Therefore, for modern people, it is very important to understand the relevant common sense of Henoch-Schonlein purpura nephritis, and then find a treatment method in time, so as to stay away from the troubles of the disease.

Differential diagnosis of Henoch-Schonlein purpura nephritis

1. Acute nephritis When Henoch-Schonlein purpura nephritis occurs when the rash has subsided, it needs to be differentiated from acute nephritis. At this time, inquiring about the medical history, including reviewing the rash morphology, distribution, joint and gastrointestinal symptoms, can help diagnose this disease. The absence of the above symptoms and early decrease in serum complement are helpful in the diagnosis of acute nephritis.

2. Lupus nephritis: Since systemic lupus erythematosus may cause rash, joint pain and kidney damage, it must be differentiated from this disease. The rash of Henoch-Schonlein purpura nephritis and the rash of lupus erythematosus are significantly different in morphology and distribution, and diagnosis is not difficult. There are differences in the renal biopsies of the two. For example, in immunofluorescence examination, although lupus nephritis also has IgA deposition, there are often large amounts of other immunoglobulin deposition and C1q deposition. The annular changes in the glomerular capillary wall of lupus nephritis can also help in differentiation.

3. Polyarteritis This disease may be similar to this disease clinically, but serum IgA is usually not elevated, and there is no IgA deposition in skin and kidney biopsies, and immunofluorescence fibrinogen is negative. In addition, this disease is rare in adolescents aged 5 to 15 years old.

4. IgA nephropathy Although this disease is different from IgA nephropathy clinically, the renal histological examination is very similar. Most of them have IgA deposition in small blood vessels of the skin, so it is difficult to distinguish the two from a histological point of view. A recent report showed that the only difference is that monocytes and T lymphocytes are often present in the renal tissue of Henoch-Schonlein purpura nephritis, but such cells are absent in IgA nephropathy. In addition, IgA nephropathy has no skin lesions and no symmetrical, hemorrhagic rash.

There are many types of Henoch-Schonlein purpura nephritis, so for modern people, this disease should be treated differently. Of course, the most important thing is to go to the hospital for a detailed examination in time, and then choose a treatment plan according to the doctor's advice. Only in this way can you truly stay away from the troubles of the disease and not be affected by the disease.