What are the symptoms of lymphoma and what changes will occur in the skin?

What are the symptoms of lymphoma? What changes may occur in the skin?

Because lymphatic tissue is distributed throughout the body, the clinical manifestations of lymphoma vary depending on the location and extent of the lesion. Primary lesions can be seen in lymph nodes or organs other than lymph nodes, such as tonsils, nasopharynx, gastrointestinal tract, spleen, bones, and skin.

Extranodal disease mainly occurs in non-Hodgkin lymphoma. The disease can metastasize from the primary site to adjacent lymph nodes, such as Hodgkin, or skip adjacent lymph nodes and metastasize to distant lymph nodes, which is common in non-Hodgkin lymphoma.

Symptoms of lymphoma include:

1. Systemic symptoms: Malignant lymphoma may cause systemic symptoms such as fever, itching, night sweats, and weight loss before or at the same time as the discovery of swollen lymph nodes.

2. Immune and blood system manifestations: 10% to 20% of patients diagnosed with malignant lymphoma may have anemia, some patients may have white blood cell count, thrombocytosis, rapid increase in erythrocyte sedimentation rate, and some patients may have leukemoid reactions with significant increase in neutrophils. The increase in lactate dehydrogenase is related to tumor load. Some patients, especially those in the advanced stage, have abnormal immune function. B-cell NHL monoclonal immunoglobulins can be detected in the serum of some patients.

3. Skin lesions: Patients with malignant lymphoma may have a series of non-specific skin manifestations, including polymorphic skin lesions, erythema, blisters, erosions, etc. Patients with advanced malignant lymphoma have low immune status, and skin infections often rupture and exude, resulting in scattered skin thickening and dandruff throughout the body.