How high is the alpha-fetoprotein to indicate liver cancer

An increase in alpha-fetoprotein levels does not necessarily mean liver cancer. Alpha-fetoprotein AFP is a biomarker used to assist in the diagnosis of liver cancer, but it is not absolutely reliable. Understanding its changes at different stages can help us better determine whether there is a risk of liver cancer.

1. Normal value of alpha-fetoprotein: When the alpha-fetoprotein level is lower than the normal value, there is usually no need to worry too much about the risk of liver cancer. However, this does not mean that the possibility of liver cancer is completely ruled out, because some liver cancer patients may not have high alpha-fetoprotein levels. This situation is medically known as "alpha-fetoprotein negative liver cancer". Although it is uncommon, it also needs attention.

2. Mild increase in alpha-fetoprotein: If alpha-fetoprotein is slightly elevated, more frequent monitoring is usually recommended, such as monthly reexamination. If the alpha-fetoprotein level is gradually increased during multiple reexaminations, this should be a cause for concern, as it may indicate the risk of liver disease. In addition to alpha-fetoprotein, imaging examinations such as ultrasound and CT should also be combined for further evaluation.

3. Significantly elevated alpha-fetoprotein: When the alpha-fetoprotein level is significantly elevated, usually greater than 100ng/ml, this is often a signal that requires special attention. Although high levels of alpha-fetoprotein do not necessarily represent liver cancer 100%, it does increase the possibility of liver cancer. In this case, combining liver function tests and imaging tests can more accurately determine whether liver cancer exists.

4. Liver damage and elevated alpha-fetoprotein: Sometimes, elevated alpha-fetoprotein may be related to liver damage rather than liver cancer. For example, in liver diseases such as acute hepatitis or cirrhosis, the regeneration of damaged liver cells may lead to elevated alpha-fetoprotein levels. If liver function indicators improve through treatment, alpha-fetoprotein levels will also decrease, which often does not support the diagnosis of liver cancer.

5. Importance of comprehensive judgment: When judging whether alpha-fetoprotein indicates liver cancer, we cannot rely on just one indicator, but need to conduct a comprehensive analysis based on the patient's medical history, other liver function indicators, imaging test results, etc. Especially for patients with a history of liver disease, such as hepatitis B, hepatitis C or cirrhosis, regular physical examinations are needed to detect possible lesions early.

Through the above understanding, we can better understand the role of AFP in liver cancer diagnosis. Even if the AFP level is abnormal, do not panic too much. You should consult a professional for a comprehensive examination and evaluation in time. Maintaining a healthy lifestyle and regular physical examinations are the key to preventing liver cancer.