Is renal hamartoma hereditary?

The cause of renal hamartoma has not been fully clarified, and it may be related to gene mutation. In addition, there are literature reports that renal hamartoma caused by tuberous sclerosis accounts for a certain proportion, and there are also some sporadic cases. Regardless of the cause of the disease, patients need to receive targeted treatment according to the actual situation to control the progression of the disease as much as possible.

The cause of renal hamartoma is still unclear. It is currently considered to be a benign genetic disease. The cause may be related to X chromosome inactivation and mutation or gene heterozygosity loss. This disease grows slowly, and the tumor will destroy normal kidney tissue as it grows progressively. Although people with this disease have no obvious symptoms in the early stages, as the tumor continues to expand, it will cause related clinical symptoms. The specific clinical symptoms are related to the size and location of the tumor, as well as the presence or absence of rupture, bleeding and other factors. Then let me give you a detailed introduction to the symptoms of renal hamartoma.

As the size of renal hamartomas continues to increase and compress surrounding tissues, dull pain in the waist and abdomen will occur. In addition, those with severe kidney compression may also develop hypertension, which manifests as tinnitus, dizziness, etc. A small number of patients will have hematuria, which manifests as meat-washing water-like urine. In addition, some patients with renal hamartomas related to tuberous sclerosis will have symptoms such as huge abdominal masses and acute retroperitoneal hemorrhage due to the rapid progression of the disease. Among them, huge abdominal masses manifest as abdominal pain and bloating, and acute retroperitoneal hemorrhage manifests as coma and decreased blood pressure.

In order to reduce the impact of the disease and prevent complications such as aneurysms, shock, impaired renal function, and acute massive bleeding, patients need to receive treatment as soon as possible. Generally, the preferred method for this disease is surgery, such as nephrectomy and preservation of renal units. These surgeries can eliminate patient symptoms, protect residual renal function, and prevent spontaneous rupture and bleeding of fluid. In addition to surgery, patients can also be treated with everolimus, minimally invasive interventions, and other methods, including cryoablation and microwave ablation.

From the above introduction, we can know that renal hamartoma has a great relationship. It is recommended that family members have regular physical examinations and make preventive preparations so as to detect and treat it as early as possible, reduce damage to the kidneys, and avoid the occurrence of renal failure. For those who are already ill, they need to follow the doctor's advice for targeted treatment to improve symptoms, delay the progression of the disease, and improve the quality of life.