Is psa6.5 an early stage of prostate cancer?

A single PSA value of 6.5ng/ml cannot indicate whether a patient has prostate cancer. It is necessary to comprehensively consider whether the patient has other influencing factors. Generally, ultrasound examinations are performed on patients before diagnosis, especially prostate MRI examinations, to further help with differential diagnosis.

However, an increase in clinical PSA can indicate and warn of prostate cancer, but there are two other indicators of prostate-specific antigen that can be used for reference, including free PSA, i.e. fPSA, and total PSA, i.e. tPSA. The ratio of the two can be used to preliminarily judge prostate diseases.

If the ratio is increased, it means that the fPSA level is increased and the tPSA level is decreased, which is a benign prostatic hyperplasia inflammatory disease. If the ratio of the two is decreased, it indicates that the fPSA is decreased and the tPSA is increased, especially when the tPSA level exceeds 10ng/ml, you should be highly vigilant about the possibility of prostate cancer. It is recommended that patients undergo further rectal examination, prostate color Doppler ultrasound examination, and prostate magnetic resonance imaging.

If rectal examination reveals that the prostate is hard and has nodules, color Doppler ultrasound of the prostate finds that the periphery of the prostate has low echoes, and magnetic resonance imaging of the prostate finds that the periphery has low signals, then the possibility of prostate cancer is highly considered. A prostate puncture biopsy should be performed under the guidance of B-ultrasound, and pathology can determine whether it is prostate cancer.

In addition, PSA is prostate-specific antigen, which is a tumor marker for prostate cancer. However, a high PSA does not necessarily mean prostate cancer. PSA is not only produced by tumor tissue, but also by normal prostate tissue. Patients with prostate hyperplasia will have elevated PSA. There are many factors that affect PSA, including inflammation and urine retention.

In addition, when doing rectal or urethral examinations, such as anal digital examinations, PSA increases, and PSA increases after inserting a catheter into the patient. Some invasive examinations such as cystoscopy can also cause PSA to increase, and PSA increases after normal sexual intercourse and ejaculation.